This research showed that lactic acid could promote protein lactylation in a dose-dependent manner in #melanoma cells. 👉 Lactic acid could significantly reduce melanin synthesis both in vitro and in vivo. go.nature.com/3GWs2uQ

In this lebrikizumab study in patients with skin of color and moderate-to-severe #AtopicDermatitis (AD), lebrikizumab improved signs and symptoms of AD and confirmed its favorable safety profile. Dig into the findings: bit.ly/4kTY34H

This review discusses what is known about the genetics of #acne, and what it teaches us about the pathogenesis of this common skin disorder. 🔎 Give it a read: bit.ly/4f8KPzN

Investigators highlight the role of DGAT2 and lipid metabolism in the pathogenesis of #psoriasis and reveal their interaction with immune responses in psoriasis. 💡 A deep dive in JCI insight: bit.ly/3TXey4X

Mitochondria-driven pseudohypoxic induction is critical for sustaining HIF1 signaling in metastasizing #melanoma cancer cells and can be exploited to develop anti-metastatic therapies, report Dr. Byoung Heon Kang and team. 📝: go.nature.com/41d65OV | Signal Transduction and Targeted Therapy(STTT)

Dr. Jun-jiang Chen and team reported that the depletion of TRIM3 strengthens the proliferation and mobility of #melanoma cells, and suppresses cell apoptosis, but these phenomena were counteracted by YAP1 down-regulation. | Scientific Reports go.nature.com/4obRXPR

Dr. Laura Hansen and colleagues at CreightonSOM provide new insight into the biogenesis and trafficking of epidermal lamellar bodies and broadly suggest that the Flower isoform, hFWE4 may serve as a core component of LRO trafficking machinery. 🌸 go.nature.com/3IONxhT

🔎 This study explores the molecular functions of TRIM3 in #melanoma cells. Depletion of TRIM3 strengthened the proliferation of melanoma cells and suppressed cell apoptosis, but these phenomena were counteracted by YAP1 down-regulation. 🔗 go.nature.com/4obRXPR

A deeper understanding of their regulatory mechanisms may provide novel strategies for managing hair diseases. 💭 Learn more about the functional roles of transient receptor potential channels in #HairFollicle biology. 📚 bit.ly/4mrt69f

Researchers propose that supersulfide in the skin may represent a novel mechanism of re-epithelialization and may serve as a therapeutic target for skin wounds. 🎯 🔗 bit.ly/44V1Dqy

Via ectopic overexpression of four neuronal transcription factors, scientists transdifferentiated #melanoma cells into neuron-like cells expressing neuronal markers and showing a neuron-like morphology. 🧫 go.nature.com/45fFNge | CDD press

This Scientific Reports study led by Dr. Faraz Adil was conducted to study the effect of #heparin as a topical wound dressing to improve healing time at donor site. 🩹 👉 Read their findings here: go.nature.com/4frR5mk

Nemvaleukin alfa demonstrated manageable safety and antitumor activity, alone and in combination with pembrolizumab, across heavily pretreated advanced solid tumors in the ARTISTRY-1 study. #Melanoma 🩺 More in Journal for ImmunoTherapy of Cancer: bit.ly/45dpm3W

New research published in BMC Biology identified a CD24+CD271+ minority sub-population in #melanoma that possesses the stem cell characteristics of lineage plasticity and self-renewal. 🧫 Learn more from Dr. Adrian Biddle and collaborators. 👇 bit.ly/3HpJQi5

Scientists led by Drs. Ivan Litvinov and Richie Jeremian utilized targeted and multi-omics approaches to explore gene expression patterns at protein and RNA levels of #MerkelCellCarcinoma. 🧬🎯 👀 Don't miss this one! bit.ly/4op88JO

Scientists investigated the role of Ym1 in both mannan and imiquimod-induced #psoriasis-like dermatitis models, using Ym1-deficient congenic mice. They show that Ym1 regulates γδT cell-derived IL-17 production and keratinocyte functionality. 🥼 💡 go.nature.com/3HgZPiB

Drs. Xingyuan Jiang, Keith Choate, and Richard Lifton led this PNASNews study which identified a recurrent de novo damaging variant in EMP2, a gene not previously associated with PSEK skin disease. 🔎 Learn more: bit.ly/4mmgQXR

The solute carrier (SLC) superfamily is responsible for the transport of a range of metabolites. This review explores our current understanding of the role of the SLC family in the pathogenesis of inflammatory skin diseases and #SkinCancer. 📚 bit.ly/4lC0Jo4

Overactivation of inflammatory signaling in keratinocytes is critical for psoriatic skin inflammation. The cytokine CSBF inhibits both individual and synergistic proinflammatory signaling induced by IL-17A and TNF-α in #keratinocytes 📝: go.nature.com/41KzO1Z

On-skin epidermal electronics, distinguished by their excellent conformability, breathability, and mechanoelectrical robustness, offer a promising solution for high-fidelity, long-term health monitoring. 📚 Learn more in this new review: bit.ly/4mi54xx