On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is ... biorxiv.org/content/10.110… #biorxiv_genomic

A recent study reported a surprisingly low overlap between TF binding and regulatory targets. But this may depend on how binding sites are defined, as we report; Should one include all statistically significant peaks or focus on top-bound targets? biorxiv.org/content/10.110…

🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis with: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results that let you

The deadline for common entrance exam (JGEEBILS) for I-PhD and PhD is on 26th October. Please apply! National Centre for Biological Sciences Tata Institute of Fundamental Research

Obituary: John Gurdon (1933-2025) Biologist who made cloning possible go.nature.com/4oyd8eC

最新の研究成果がNature誌に掲載されました！ショウジョウバエを用いて、神経由来のペプチドCapaが、カルシウム動員ホルモンとして体液中のカルシウムを調節することを発見しました！骨を持たない昆虫にも、脊椎動物のPTHに相当する内分泌システムがあることを示しました。 nature.com/articles/s4158…

#imsorryjon

.Nature Genetics paper by bizarMD Herbert Irving Comprehensive Cancer Center Cellular states associated with metastatic organotropism & survival in patients with #PancreaticCancer “pre-existing cellular states within primary tumors appear to guide organ-specific metastatic relapse” nature.com/articles/s4158…

1/ Excited to share our new study with Brumbaugh Lab, now out in Nature Biotechnology! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…

Nature research paper: Evidence for improved DNA repair in long-lived bowhead whale go.nature.com/3Lzg1NH

(1/10) How do diverse leukemia mutations converge on the same molecular program? In our new study Cell,the Riback Lab - Cellular Physical Chemistry Group and Peggy Goodell show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧

The Median Preoptic Nucleus is a Key Site for Estradiol Regulation of Sleep-Wake Behaviors in Females Rats biorxiv.org/content/10.110… #biorxiv_neursci

That was such a nice talk Amanjot Singh ! Great new insights on stress granules and the RNA in/outside them! Manipal Institute of Regenerative Medicine #emboccmb25

I have had the best luck to work with Dr. Bert O’Malley on a few things and have benefited from his leadership, mentorship, wisdom, and kindness! He will be missed!

Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's Disease | Disease Models & Mechanisms | The Company of Biologists journals.biologists.com/dmm/article/do…

Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the ... biorxiv.org/content/10.110… #biorxiv_molbio

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut go.nature.com/4i7XnZR

The ZeitlingerLab is pleased to announce Melanie Weilert’s preprint “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (biorxiv.org/content/10.110…). Summary below! (TLDR; low-affinity motifs are common and strong pioneers in vivo!)

おもしろ。 A global screen for magnetically induced neuronal activity in the pigeon brain | Science science.org/doi/10.1126/sc…

New work reveals Gyc76C as the receptor for the anti-diuretic hormone ITPa in flies, uncovering how it helps control hydration and metabolic balance. elifesciences.org/articles/97043…