🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

📢Out now! Xihao Li, Pradeep Natarajan, Zilin Li, Zhonghua Liu, Xihong Lin, and colleagues from NIH NHLBI present a framework for functionally-informed multi-trait rare variant analysis of biobank-scale sequencing studies. nature.com/articles/s4358… 🔓rdcu.be/d82Fx

Great collaboration spearheaded by Xihao Li Zilin Li Zhonghua Liu Xihong Lin now out in Nature Computational Science! Broad Institute MGH Cardiovascular Research Center CGM at MGH @MGH_RI Harvard Medical School Harvard T.H. Chan School of Public Health

We're thrilled to share our latest publication, A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies, in Nature Computational Science. Sincerely thanks to Xihong Lin for incredible mentorship, Zilin Li, Zhonghua Liu, Pradeep Natarajan, Dr.

We have also developed offline pipelines (github.com/PennPRS/pipeli…) for ten PRS methods and applied our pseudo-training pipelines to over 8,000 phenotypes from diverse global biobanks and made these trained PRS models publicly accessible (pennprs.org/result).

Check out Jin Jin 's awesome work on building a cloud-computing platform for online PRS training 👍

Jane Ha Andy Chan Lisa Strate Clinical & Translational Epidemiology Unit - MGH Mongan Institute Very proud to share our work on visceral fat quantified by a deep-learning algorithm and risk of incident and recurrent diverticulitis using MGB Biobank data! journals.lww.com/dcrjournal/abs…

Join our CTEU Seminar on 3/12 at 9 AM. Dr. Andrew H. Song from the Brigham and Women’s Hospital will give a talk entitled “When AI meets pathology – Harnessing AI for improved patient care.” Chat with us at mghcteu.org to join Zoom.

The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our Nature paper: nature.com/articles/s4158…

Join our CTEU Seminar on 4/2 at 9 AM. Dr. Jin Jin from the University of Pennsylvania will give a talk entitled “PennPRS: a centralized cloud computing platform for efficient polygenic risk score training.” Chat with us at mghcteu.org to join Zoom.

On the heels of our two collaborative studies connecting clonal hematopoiesis to kidney outcomes (journals.lww.com/jasn/abstract/… & journals.lww.com/jasn/abstract/…), delighted to share our review synthesizing the evidence to-date on clonal hematopoiesis and kidney disease led by Zhi Yu

Growing evidence links clonal hematopoiesis🧬to kidney disease 🫘 Check out a review of recent findings by us Pradeep Natarajan Caitlyn Vlasschaert on JASN_News -including our latest collaborative work on same journal—as we unravel this important connection: journals.lww.com/jasn/abstract/…

Join our CTEU Seminar on 4/23 at 9 AM. Dr. Satoshi Koyama from the Broad Institute will give a talk entitled “Advances and Challenges in Cardiovascular Disease Genetics across the Common‑to‑Rare Variant Spectrum.” Chat with us at mghcteu.org to join Zoom.

Study finds that Non-DNMT3A CHIP was associated with CKD progression among individuals with CKD, and Tet2-CHIP mouse models support a causal role in kidney injury. bit.ly/JASN0680 #ASNJASN

In patients with CKD, non-DNMT3A CHIP was associated with cardiovascular disease with an effect size similar to that reported in the general population. bit.ly/JASN0671 #ASNJASN

📣 The recording of "A Practical Primer on Bayesian Statistics" by Sarah Urbut is now available: youtube.com/watch?v=jcFSuk… This talk is part of Broad Institute's MPG Primer series. For more info, check out broad.io/MPGPrimer

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! Sarah Urbut's talk to Broad Institute BroadMPG : A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFSuk… We are incredibly lucky to have her

am: Received my 2nd Tiger Award🐯—Early Career Achievement—from one of my favorite meetings, CHARGE consortium. Many thanks to my mentors Andy Chan Pradeep Natarajan! pm: Attended farewell to Tim Coorens, a peer whom I learned immensely from. Grateful for such a meaningful day : )

Research suggests Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to CKD and its comorbidities. This Review underscores the need for further research to identify the distinct pathways through which CHIP may contribute to CKD & its comorbidities.

Join our CTEU Seminar on 5/21 at 9 AM. Dr. Zhi Huang from the University of Pennsylvania will give a talk entitled “Human-AI collaboration for pathology image analysis and clinical decision-making.” Chat with us at mghcteu.org to join Zoom.

HUGE congrats to graduating MGH Cardiology Fellows Sarah Urbut Sumeet Khetarpal, both 🌟 preventive cardiologist-scientists, for receiving Burroughs Wellcome Fund Career Awards for Medical Scientists!! We are thrilled that Sarah Urbut will stay with us Mass General Heart Broad Institute & also