📈 Read one of our recent most read #OpenAccess articles, "Improving Protein Expression, Stability, and Function with ProteinMPNN" Jimenez-Oses Lab Institute for Protein Design CIC bioGUNE BRTA - Basque Research and Technology Alliance Ikerbasque Read the article here ➡️ go.acs.org/7Kk

With transformer #AI protein design and major advances in DNA synthesis, how do we deal with biosecurity concerns? Editorial Science Magazine science.org/doi/10.1126/sc… David Baker Institute for Protein Design and george church

Our work on modeling and designing biomolecular assemblies is now in Science Magazine. science.org/doi/10.1126/sc… RFAA Code: github.com/baker-laborato… RFdiffusionAA Code: github.com/baker-laborato…

Paper is now live on Science Magazine! Congrats to Rohith Krishna Jue Wang Woody Ahern for leading this work. Big leap for protein modeling and design! Paper: science.org/doi/10.1126/sc… Code: github.com/baker-laborato…

Signed. A good idea for safety in protein design (AI powered or not): regulate and control the protein synthesis machines and firmware, not the AI research itself. This is an idea I promoted at the UK AI Safety Summit.

Protein binding a small molecule designed with RFDiffusion-AA yesterday. I'm such a huge fangirl for these all-atom models. Baker Lab is awesome!

Scientists are getting ahead of potential downsides of #AI for protein design. There are so many compelling and important uses for new #proteins #enzymes. nytimes.com/2024/03/08/tec…

Protein design pioneer David Baker on why sharing code is key to building biotech startups. Institute for Protein Design Charlotte Schubert GeekWire bit.ly/49LEyGD

Our director David Baker recently shared his thoughts on the impact of AI on life sciences and healthcare startups. He spoke with Jenny Cronin at a UW CoMotion event. ipd.uw.edu/2024/03/david-…

Super excited to finally see the publication of this great paper in nature; this was one of the first projects I got to work on in grad school! Home Depot inspired #ProteinDesign Institute for Protein Design Work led by Tim Huddy Ryan Kibler Yang and Jinwei Xu nature.com/articles/s4158…

We’re excited to share our preprint where we show, for the first time, the atomically accurate design of VHH antibodies!

Structure-based VHH design preprint is now up! Nate Bennett Joseph Watson Rob Ragotte Andrew Borst and special shoutout to DeJenae See and Buwei who I collaborated with on this study. Watch this space closely, there's more coming :) Institute for Protein Design biorxiv.org/content/10.110…

We’re really happy to share our preprint demonstrating the atomically-accurate design of single-domain antibodies (VHHs) with RFdiffusion!

Register today for this free SynBioBeta event: synbiobeta.zoom.us/webinar/regist…

“I believe this collaboration between a stem cell institute, a dental school, and experts in genetic sequencing and protein design could only happen in a few places, and one of them is in Seattle.” UWDentalSchool Ruohola-Baker Lab Institute for Protein Design Brotman Baty bit.ly/4aIfBMT

Finally our work on designing pH responsive antibody nanoparticles capable of disassembling at ~tunable~ pH, packaging and releasing cargo, and targeting specific cell surface receptors is out in NatureStructMolBiol! nature.com/articles/s4159…

#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge. This collaborative project was led by Cara Chao and is out now on bioRxiv: biorxiv.org/content/10.110…

Protein-based agonists generated from our de novo protein minibinder pipeline bind to human #TLR3 with nanomolar affinities. This collaborative project was led by recently graduated Dr. Chloe Adams and is out now on bioRxiv: biorxiv.org/content/10.110…

An #mRNA vaccine encoding for a secreted RBD nanoparticle elicited potent, broad, and protective antibody responses and induced robust antigen-specific CD8 T cell responses. A collaborative project led by Grace Hendricks; out now on bioRxiv: biorxiv.org/content/10.110…