ASCI member Markus D. Siegelin Columbia University in JCI insight:
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma: buff.ly/4aNxF8o

#Oncology

ASCI member James Zimring UVA School of Medicine in Journal of Clinical Investigation:
Complement C3 and marginal zone B cells promote IgG-mediated enhancement of RBC alloimmunization in mice: buff.ly/3Qi8J0C

#Immunology

ASCI members G.R. Scott Budinger and Benjamin D. Singer on JCI insight's #Cover : Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with #COVID_19 : buff.ly/4cZwSmf
Benjamin D. Singer Northwestern Medicine
#ClinicalMedicine #Immunology

ASCI members Samir Parekh and Amit Verma Amit Verma in Journal of Clinical Investigation: Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency: buff.ly/3w6wth7
Icahn School of Medicine at Mount Sinai Albert Einstein College of Medicine - Official
#Oncology

Up next in the ASCI Scientific Sessions:

Emily Wang

'Can we achieve health equity without ending mass incarceration?'

May 10, 1-2pm ET

Moderated by Susan Cheng, MD, MMSc, MPH Cedars-Sinai Academic Medicine

Free and open to all!

Register: buff.ly/4d8VsBk

ASCI member Bruce R. Blazar Masonic Cancer Center, University of Minnesota in Journal of Clinical Investigation:
Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation: buff.ly/49xpuvz

#100th #Anniversary #Viewpoint

ASCI member Thomas B. Nutman NIAID News in JCI insight:
Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humans: buff.ly/4cOtIln

#Immunology #InfectiousDisease

ASCI member Hideho Okada UC San Francisco in JCI insight:
Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment: buff.ly/4akJtPb

#Immunology

ASCI member Kornelia Polyak Polyak Lab Dana-Farber:
HER2 heterogeneity and treatment response–associated profiles in HER2-positive breast cancer in the NCT02326974 clinical trial: buff.ly/4cJYFXT

#Oncology
#ClinicalMedicine

ASCI member James Brugarolas UTSW Simmons Cancer Center in Journal of Clinical Investigation:
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis: buff.ly/3xvn972

#CellBiology #Oncology

ASCI member Paul Rosenberg Duke University School of Medicine in Journal of Clinical Investigation:
The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice: buff.ly/4cS3tdN

#CellBiology #MuscleBiology

ASCI member Samuel Refetoff UChicago Medicine on @JCI_insigh's #Cover : Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome: buff.ly/3VXioNs

#Endocrinology #Neuroscience

ASCI member Lawrence Corey University of Washington in Journal of Clinical Investigation:
Anti–PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers: buff.ly/3vNtdqM

#AIDS #HIV #Therapeutics

ASCI member J. Michelle Kahlenberg Michelle Kahlenberg Michigan Medicine in JCI insight: Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease: buff.ly/3U1ESM9

#Dermatology

ASCI member Alan Hanash Memorial Sloan Kettering Cancer Center in Journal of Clinical Investigation: Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage: buff.ly/3VPGJoJ

#Immunology #Transplantation

#Review by ASCI member Nicole Calakos PhD MD Duke University School of Medicine in Journal of Clinical Investigation: The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia: buff.ly/43EeLy3

100th Anniversary #Viewpoint by ASCI member Arturo Casadevall Johns Hopkins Bloomberg School of Public Health in Journal of Clinical Investigation:
Pandemics past, present, and future: progress and persistent risks: buff.ly/3J27COw

.ASCI honors Howard Chang Howard Chang with the 2024 Stanley J. Korsmeyer Award for his contributions to genome science through his invention of mapping technologies and his discoveries of long noncoding RNAs (lncRNAs). buff.ly/3xjOvwO

ASCI member Roberto Civitelli Washington U. Med in JCI insight: Connexin43 in mesenchymal lineage cells regulates body adiposity and energy metabolism in mice: buff.ly/4aiDJ8z

#Metabolism

ASCI member Muneesh Tewari Muneesh Tewari Lab Michigan Medicine in JCI insight: ctDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer: buff.ly/43N7Vq9

#ClinicalMedicine
#Oncology