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Protein expression is still a bottleneck for synthetic biology. Our review in Trends in Biotechnology maps what’s been engineered, and what’s still missing. Predictable expression is key to scaling bio. Thanks to our collaborators; excited to see this reach a wider audience! 🔗

OligoSeq: Rapid nanopore-sequencing of single-stranded oligonucleotides biorxiv.org/content/10.110… #biorxiv_synbio

The approved drug methotrexate can potentiate antitumor immune activity and shows signs of boosting the efficacy of checkpoint blockade immunotherapy in patients with solid tumors, according to a preliminary clinical trial. Learn more in Science Translational Medicine: scim.ag/4kYO8ez

Leonard Rome’s lab discovered an odd, abundant component of cells in the 1980s—and he’s still trying to figure out what it does. Learn more in this News from Science feature: scim.ag/40arg4a #ScienceMagArchives

Just published Science Magazine Engineering T cells within the body, a big step forward for treating cancer and autoimmune diseases, as demonstrated in animal models science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

CD8-targeted lipid nanoparticles carrying anti-CD19 CAR mRNA were developed to generate CAR-T cells directly in vivo, demonstrating effective B cell depletion for potential treatment of B cell malignancies and autoimmune diseases. science.org/doi/10.1126/sc… #NBThighlight

Super excited about our recent paper describing a high throughput screen for functional variants in the context of APDS. Rare disease ain’t always that rare! Great collaboration with Ben Izar and Dusan Bogunovic! cell.com/cell/abstract/…

Emily Alsentzer Michelle M. Li (李敏蕊) Isaac Kohane Shilpa N. Kobren Ayush Noori UDN DBMI at Harvard Med Harvard Medical School Kempner Institute at Harvard University HST 🧬 Bonus features: * “Patients‑like‑me” retrieval: finds cohort analogs quickly * Characterisation of novel/differently presenting cases * Attention maps point to key clinical phenotypes that drove predictions 💡 Why it matters: Accessories to current pipelines, SHEPHERD can

Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells - Peking University bit.ly/4llylGS

Leveraging synthetic biology techniques, researchers have engineered a strain of Salmonella that can stimulate mature tertiary lymphoid structures to augment antitumor immunity and shrink colorectal cancer tumors in mice. Learn more in Science Translational Medicine: scim.ag/4naECqz

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science science.org/doi/10.1126/sc…

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity | Nature Communications nature.com/articles/s4146…

BioEmu now published in Science Magazine !! What is BioEmu? Check out this video: youtu.be/LStKhWcL0VE?si…

Why do wounds in the mouth heal without scars? New work in Science Translational Medicine shows that oral fibroblasts suppress fibrosis through the proteins AXL and GAS6, and finds stimulating AXL recapitulates these benefits in facial skin wounds in mice. scim.ag/46xnJ3t

New, important insights for neurodegenerative diseases by high-throughput proteomics today #GNPC 1. APOε4 carriers have a distinct pro-inflammatory immune proteomic signature of dysregulation in the brain and blood Nature Medicine nature.com/articles/s4159…

Good explainer of a key report nature.com/articles/d4158…

Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients rupress.org/jhi/article/1/…

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology | Science Advances science.org/doi/10.1126/sc…

Online Now: Nucleosomes specify co-factor access to p53 dlvr.it/TM6W0T

Data from the second human treated with a prime edited medicine: a 56-year-old male with chronic granulotamous disease (CGD) had his bone marrow prime edited to insert the missing GT in NCF1, restoring NADPH oxidase function in neutrophils (DHR positivity) several fold beyond the