I am extremely proud to see our work about Hepatitis B now published in Cell. From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 cell.com/cell/fulltext/…

BIG NEWS in Cell Reports! Adhesion strength of tumor cells predicts metastatic disease in vivo cell.com/cell-reports/f… In this work, we show that a physical property - adhesion strength - stratifies mouse and patient samples into disease and non-disease subtypes. (1/4)

This is an absolutely incredible milestone, and it has been inspiring to see Miquel and his team move this into the clinic.

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions - now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators! biorxiv.org/content/10.110…

The final version of our protein transposition manuscript is now published in Science Magazine science.org/doi/10.1126/sc… We’ve added a few new things since our preprint /1

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason Sean McGeary Allon Klein Lab 1/20 doi.org/10.1101/2025.0…

🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…

🌟Financing milestone! #SpliceBio closes $135M Series B to: 🚀Advance SB-007 for #StargardtDisease 🔬Expand our genetic medicine pipeline Read more: bit.ly/3ZpxYmi

Please help get the word out - We are hiring at all levels (postdocs, grad students, and postdocs)! If you are interested in sponges, evolution, cell biology, and symbiosis, please don't hesitate to reach out and learn more about the opportunities in our lab.

1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by Tom Golde 🙌 IBEC biorxiv.org/content/10.110…

New in Science Magazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 : doi.org/10.1126/scienc…

The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science. Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving  4–22% success rates with efficient experimental

🚨 I'm hiring at all levels! Interested in animal origins & evolutionary cell biology? I'm recruiting a postdoc, PhD students & a research assistant to study the evolution of cell adhesion using marine inverts + comparative genomics. 🔗: clarkelab.com/join/ Please repost!

Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology! Check it out! 📜: nature.com/articles/s4158… Thanks to UW News for the feature write-up! washington.edu/news/2025/10/0…

Congratulations to the impressive list of Penn scientists awarded @NIHDirector's high-risk, high-reward research grants! These #NIHHighRisk awards fund innovative & impactful biomedical research. Check back as we profile each winner➡️ tinyurl.com/2prk75be

Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (Cell Biomaterials, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : cell.com/cell-biomateri…

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-conf…

Happy to share that this work is now published in Biophysical Journal! doi.org/10.1016/j.bpj.…

We are searching for computational PhDs and Postdocs to join our group in collaboration with Treutlein lab . We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to [email protected]