PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry | Science Translational Medicine science.org/doi/10.1126/sc…

#Aβ42 #secondarynucleation #ApoE #Alzheimers #TIRF #Microscopy #amyloid #Aβ #Aβ40

Grateful to Biopatrika for the opportunity to discuss our recent findings on ApoE’s isoform-specific effects on Aβ42 aggregation. A pleasure to reflect on the science and story behind the work! article 👉nature.com/articles/s4200… #Alzheimers #Neurodegeneration #Aβ42 #ApoE

...and big thanks to Janet Iwasa for making this amazing video to illustrate the strand-sliding mechanism!

'Never rely on an authority in science. Even the greatest genius can be wrong — whether he has one or two Nobel prizes, or none.' -Erwin Schrödinger

Excited to share our work just published in Angewandte Chemie Happy to be part of this research👩‍🔬 We demonstrate the the impact of counterion choice on the aggregation and resulting different emissive state of organic salts! Chemistry at York mcgonigalgroup doi.org/10.1002/ange.2…

Fresh off the press! Simran Rawal (Tamal Das's lab TIFR Hyderabad) & colleagues find out how organelles inside epithelial cells (lining a wound) reorganise themselves & opt for specific known migratory modes in response to different curvatures of wounds. nature.com/articles/s4155…

FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online The EMBO Journal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n

This 1998 paper is, without question, one of the most beautiful in the history of biology. It answers two questions: First, how does a potassium channel let in K+ ions while excluding Na+ ions? And second, how does it funnel 100 million of those ions through each second? These

A proud moment for IISER Mohali. A hard work well paid for my dear colleagues, Ruchita and Rhitoban, with this wonderful discovery on How termites save their fungal crop from weed invasion. IISER Mohali | Science science.org/doi/10.1126/sc…

Your cells (and not just the ones in your brain) remember. Fat cells retain an “obesogenic memory” after weight loss: an energetic imprint that primes them to store again. Viewed through the Energy Resistance Principle (ERP), this is a regulatory strategy for energy efficiency.

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency nature.com/articles/s4146…

Happy to see that our lab’s open-science tool, GScholarLens has been featured by nature. Dalmeet Chawla (Dalmeet Singh Chawla | ਦਲਮੀਤ ਸਿੰਘ ਚਾਵਲਾ) does a fantastic job highlighting how GScholarLens brings transparency to scientific metrics, helping researchers, institutions, and the community better

Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release | PNAS pnas.org/doi/10.1073/pn…