For readers interested in lipid nanoparticles for nucleic acid delivery, here's a perspective by Cullis and Feldner on the evolution of the field rdcu.be/eMpeO nature.com/articles/s4157…

Elucidating lipid nanoparticle properties and structure through biophysical analyses go.nature.com/4oTt639

Excellent review by Katy Rezvani, M.D., Ph.D & Alexander Biederstädt, MD in Cancer Cell Engineered natural killer cells for cancer therapy cell.com/cancer-cell/fu…

Review Molecular Therapy Patrick Chames 🇫🇷 Nanobody-enhanced T cell cancer immunotherapy: Advancing precision medicine cell.com/molecular-ther…

Rewiring microbial metabolism through post-translational switches "Post-translational regulatory tools-synthetic degradation tags, spatial regulation via subcellular compartmentalization, allosteric protein engineering for dynamic enzyme activity control" sciencedirect.com/science/articl…

Preprint: Piezo1-mediated mechano-energetics regulate CAR T cell function researchsquare.com/article/rs-777… New York University

One Protein Is All You Need 1. A new method called Protein Test-Time Training (ProteinTTT) has been proposed to enhance the generalization of protein language models to individual proteins. This method enables self-supervised customization of models to one target protein at a

For readers interested in new approach methodologies for assessing the safety of drug candidates, here's a Perspective from an EFPIA expert group rdcu.be/eMzJ3 nature.com/articles/s4157…

Nature research paper: Bottom-up design of Ca2+ channels from defined selectivity filter geometry go.nature.com/3WV25A4

Epic. Another big step toward universal binder design. Produced nanomolar binders for 6/9 targets with no known binders and low (<30%) sequence similarity to any structural complex in the PBD. The Boltz team is unreal. All open-source and in the hands of scientists around the

NEW content online! Epigenetic regulation of T cell exhaustion in cancer bit.ly/4oHxa6h

Review Nature Reviews Cancer St. Jude Epigenetic regulation of T cell exhaustion in cancer nature.com/articles/s4156…

Postdocs, start your own RNA lab in Germany. Application deadline: end of this week. nature.com/naturecareers/…

Antimicrobial resistance: a concise update - The Lancet Microbe (thelancet.com/journals/lanmi…)

For readers interested in the potential to target particular protein isoforms as a way to achieve greater drug specificity, here's a review rdcu.be/eNiHj nature.com/articles/s4157…

In nature: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible. More here: rockefeller.edu/news/38513-maj…

Multidrug-resistant Gram-negative bacterial infections - The Lancet (thelancet.com/journals/lance…)

How Klebsiella pneumoniae controls its virulence | PLOS Pathogens (journals.plos.org/plospathogens/…)

Ongoing Eli Lilly trials Particularly interesting are the major phase 3 trials for single, dual, and triple GLP1s in such a range of conditions Inflammatory bowel disease, lower back pain, psoriasis, hypertension, stress urinary incontinence, osteoarthritis, sleep apnea...

A knock to remember! Jemimah Rodrigues' stunning hundred guides India into the #CWC25 final 👏🎉 She wins the aramco POTM award for her stellar performance 👌