$400k & 10 years for a plant in the backyard? Solving the big issues.

Childhood trauma rewires the brain: • Hippocampus (memory) shrinks • Amygdala (fear) becomes hyperactive • Prefrontal cortex (rational thought) shuts down This leaves the brain on high alert, even in safe situations.

Like I needed another excuse for a sleep in?

"Criminalisation does not help, it harms" Yet another call for the NSW government to act on evidence based advice provided in a multitude of reports.

The price of medication in the USA is mindblowing. Run of the mill depression & high cholesterol will set you back $70k / year for a statin & some fluoxetine.

Frumpy threatening a 200% tariff if we don't turf the PBS. Australia should add tariffs until the Epstein list is released.

Why so much research into addiction is plain wrong. 🧵 Addiction is not simply a compulsion or a moral failing. It is a maligned form of attachment. When early caregivers are absent, frightening, or unpredictable, the child turns to internal strategies.

I'm seeing the results of this in the hospitals; rocketing alcohol & *rug use as people try to cope. People get angrier, they become sicker, & society as a whole, pays.

The Halfway Post Epstein wasn’t one man. It was a system. And the gatekeepers are about to be exposed ..... Survivors deserve justice. Not silence bought by powerful enablers!

Fascinating

Childhood trauma drives LC hyperarousal;pioid use supresses noradrenaline,can help sleep (initially)-brain compensates by making neurons more excitable. When opioids stop,rebound noradrenergic surge in withdrawal drives hyperarousal→ anxiety→ autonomic activation → insomnia

GLP1's could be the next big thing in treating substance use with comorbid obesity

Further, 3 cups of black coffee has evidence in reducing fatty liver markers.

Do stimulants cause tolerance? ▪ Yes: For mood and rewarding qualities ▪ No: For treating ADHD From a limited database of 17 trials in new analysis: pubmed.ncbi.nlm.nih.gov/41627718

Mr Liue will be on the right side of history

Applications now open for the #NextGen Scholarship. Designed to support AOD nurses, NPs & emerging nurse leaders who demonstrate leadership, innovation & a commitment to advancing nursing practice. Applications close: 5pm, 29 March 2026 Apply: nextgennursepractitioners.com.au/ngnp-scholarsh…

This is exactly right. In our recent ADHD + Circadian review, symptom improvement occurred with 0.5 mg melatonin ~5 hours before bedtime to phase advance the clock. Melatonin should be used to shift circadian phase, not as a sleeping pill. x.com/BrandonLuuMD/s…

GLP-1s linked to 5% difference in alcohol use in a observational study (not focused on AUD): pubmed.ncbi.nlm.nih.gov/41646707 Evidence grade moderate Ozempic is proclaimed a "cure" for alcoholism in latest New Yorker, but best designed randomized trial? Negative: pubmed.ncbi.nlm.nih.gov/36066977