1/ We are excited to share our report in Journal of Experimental Medicine showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/22…).

Exposure to fungi can help sterile laboratory mice better model specific features of the human immune system, finds new research from Cadwell Lab @Grahammunology Png Loke. scim.ag/36V

Thought ticks were terrifying? They just got worse. Turns out they can use static electricity ⚡️ to launch through the air onto hosts, including you! Here's a thread about our new paper w/ Katie Lihou, Daniel Robert, out today in Current Biology doi.org/10.1016/j.cub.… 🧵👇

🚨Job Alert! My lab is looking for postdocs to study innate immunity against Toxoplasma infection and parasite proteins modulating host responses. Please check the details and apply👇

TWiV 1026: Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler & Brianne Barker. Guest: Dan Wilson. 📺 bit.ly/3PTqYtO

The lab’s first publication in Cell Reports! We show that loss of MEF2A elicits R-loop accumulation and IFN production. R-loop associated molecules, ATR and DDX41, are required for the activation of STING. cell.com/cell-reports/p…

Excited to share our work from John Schoggins lab published in EMBO Reports today. Based on our findings and others, we propose that fewer antiviral genes may be involved in viral restriction by interferon than previously thought! Check out our paper here: embopress.org/doi/full/10.15…

We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes cell.com/cell-host-micr…) 1/10

“Thanks everyone for comments on the draft, here it is revised with all your edits.”

m7GpppNm - VERY EXCITED to share my postdoctoral work in with @RamlabUW, now out @bioRxiv. We found that cellular RNA interacts with MAVS, the adaptor protein of the RIG-I-like receptor pathway, to promote antiviral signaling. "🧵": buff.ly/45bzXui

Online Now: ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation dlvr.it/Sx0J0d

1/ So proud of this major group effort! Check out our new publication in Nature Microbiology exploring the mechanism by which extracellular vesicles from the fungal pathogen Candida albicans rewire innate immunity.

First review article from my lab! Very proud of this effort by Owen Jensen and the rest of the Ost lab team. Controlling Candida: immune regulation of commensal fungi in the gut | Infection and Immunity journals.asm.org/doi/10.1128/ia…

🆕 Interplay btw host humoral pattern recognition molecules controls undue immune responses against #Aspergillus fumigatus in Nature Communications w/ Vishukumar Aimanianda at Institut Pasteur, since 1887 👉 In long : nature.com/articles/s4146… 👇 In short 🧵 1/6 #pentraxin3 #immunity