Distinct roles of CXCR3 ligands CXCL9 and 10 during chronic viral infection. CXCL10 lures CTL into the red pulp to hasten their terminal differentiation, accelerating depletion of the TCF-1+ stemlike memory pool and limiting viral control. Congrats, Ola. …edirect-com.ezp-prod1.hul.harvard.edu/science/articl…

What a phantastic idea: Using -omics computational tools to analyze intravital microscopy data on immune cell migration. Congrats, Andres, Miguel, and Georgiana, and thanks for allowing us become a (very) small part of this. rdcu.be/cExHR

If Darwin went on his voyage of the Beagle today his research would've ended with a t-SNE of the bird specimens that he collected instead of a theory of evolution

Couldn't agree more. And then there is the famous clam "chowda"

Here we reviewed MALT1 protease inhibitors as newly emerging therapeutics not only for lymphoma, but also for solid cancer, based both on their direct effects on cancer cells as well as the conversion of tumor-infiltrating Treg cells into pro-inflammatory effectors.

I am very happy to share our translational studies on Treg fragility. Mepazine works in patient-derived organotypic tumor spheroids! Great job of all team and our CEO Peter Keller! Clinical trials ongoing... Stay tuned! meridian.allenpress.com/innovationsjou…

The Mempel Lab is hiring. Interested in understanding how the #Immune System can control and eliminate #Cancer? We are looking for a #Research Technician to join our team at the @MGH_RI in Boston. For details, see: mempellab.mgh.harvard.edu/joinus.php

Why sometimes you need the PI x.com/Figensport/sta…

An impressive paper describing a remarkable advance in imaging technology and its application for intravital imaging of immune cells dynamics. A must read for any IVM aficionado.

Thanks so much for hosting me, Thomas. It was my great fortune to have you in the lab, and now seeing you succeed with your own operation is even greater reward.

Credit goes to Christopher Garris for the nice shepherding metaphor (or is it a simile 🤔?) in the title. I ll always picture T cells as little sheep from now on...

I could not agree more. It's a mystery why it hasn't happened yet.

Dendritic cells as shepherds of T cell immunity in cancer: Pittet, Di Pilato, Garris, & Mempel review the current knowledge of DC-T cell interactions at both priming and effector sites of immune responses & discuss how insights from DC development, ontogeny, and function in

Happy to share a link to our review of chemokines in cancer in Nature Reviews Cancer. We explore how chemokine programs that evolved for inflammation, tissue repair, antimicrobial defense etc shape tumor microenvironments. Tx to Lukas Altenburger and Julia Lill rdcu.be/ds6Cl

A nice intravital microscopy study illustrating how activation of Leishmania-specific Treg cells can promote reactivation of latent parasite lesions.

Join us at the 2024 Gordon Research Conferences on chemotactic cytokines, June 1-7. Explore cutting-edge, unpublished research, and enjoy interactive discussions among scientific colleagues. RT to spread the word. Apply now! #immunology #neurobiology #cancerbiology

Study host-microbe interactions in sunny San Diego, CA! Fully-funded postdoc opportunity in the Constantinides Lab Constantinides Lab Scripps Research. Please RT! Apply: bit.ly/3wuURck

Definitely one of the greatest perks of being a PI is when your former trainee starts publishing his own cool papers. Check out Francesco Marangoni's paper in Cancer Cell describing how a-PD-1 checkpoint blockade increases intratumoral Treg cell activity: sciencedirect.com/science/articl…

Yet another way chemokines do their important work, as reported by the Stein lab