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Thrilled to announce our first major breakthrough in applying AI to a grand challenge in science. #AlphaFold has been validated as a solution to the ‘protein folding problem’ & we hope it will have a big impact on disease understanding and drug discovery: deepmind.com/alphafold-blog

Neat animated plot showing daily deaths in France from 2001 to 2020. The two waves of COVID-19 are clearly seen.

New paper from the lab in Science Advances ! Hsieh et al. show how hemizygous loss of MYBBP1A promotes tumorigenesis in PDAC cells, and how PARP1 inhibition by small molecules evicts MYBBP1A from chromatin and impairs cell growth. doi: 10.1126/sciadv.abc4517

The word 'doctor' comes from the Latin word for "teacher." merriam-webster.com/words-at-play/…

Does iterative oxidation of 5mC to 5hmC/5fC/5caC facilitate reprogramming? We use TET stalling mutants in an iPSC system to show that the answer is YES. Great work by B. Caldwell, awesome collaboration with Kohli lab and fabulous colleagues. cell.com/molecular-cell…

The Pou5f1 gene folds into cell-type specific nucleosome clutch patterns bit.ly/2LJqcRs

We find no evidence that the formation of "transcriptional condensates" amplifies gene expression or increases transcription activation tinyurl.com/y56tof9c

Very excited that our review on pioneer factors during development is online now at Molecular Cell. It was fun to read the fantastic scientific literature on the subject while writing. We hope it is useful to read. Check it out: authors.elsevier.com/a/1ciLc3vVUPGJ…

Story of a 66-year-old researcher, an immigrant, who rarely got grants, never got her own lab, never earned more than $60K. For four decades, she kept working on mRNA—a path considered foolish. Her work is the basis for the Pfizer and Moderna vaccines. nytimes.com/2021/04/08/hea…

We haven't tweeted for a while but we're coming with great news! Congratulations to Ken, just elected at the American Academy of Arts & Sciences ! amacad.org/news/2021-memb…

« Je vais mourrir bientôt... » Axel Xahn, ancien président de la Ligue Natiobale contre le Cancer, condamné par un cancer dit au revoir, « souriant et apaisé ». Quelle leçon de vie ! (compte Facebook)

Just published NEJM #CRISPR genome editing for hereditary amyloidosis Dose-dependent drop of misfolded TTR protein in 6 patients, using mRNA in lipid nanoparticle intravenous infusion. nejm.org/doi/full/10.10…

C’est avec tristesse et émotion que la Ligue contre le cancer vient d’apprendre le décès d’Axel Kahn.

My & @Melike_Lak s lab are looking to jointly hire a computational specialist. The role will include developing analysis pipelines & implementing new algorithms for dealing with TB scale microscopy datasets. Please help spread the word! careers.chop.edu/job/Philadelph…

The US homicide rate jumped 25% in a single year. NY, LA and some other cities are still far from their early '90s peak, thank god. But many others are breaking records. I went to one to make sense of what's happening. Here is my story for ProPublica: propublica.org/article/philad… 1/2

All Delta here in July. The 8:1 odds are pretty good.

Please RT. We are looking for 2 postdocs to develop and apply advanced live imaging and single molecule tracking to study txn and nuclear organization. We have awesome microscopes, facilities, collaborators, funds, & are in a dynamic and affordable city! careers.chop.edu/job/Philadelph…

.Volodymyr Zelenskyy / Володимир Зеленський's tv address to the Russian (!) people might be the most moving speech that I've ever seen in my entire life. The whole world needs to see, understand and share this crucial Ukrainian message. #StandWithUkraine #Ukraine #Україна #Russia #Россия

We very much welcome Ph.D. students who are interested in investigating how chromatin behaves for its functions in living human cells using our single-nucleosome imaging: bit.ly/390MHwZ bit.ly/3m6GG8y NIG offers Ph.D. student fellowship: bit.ly/3pGqBV9

Avant-garde chromatin research in living cells in beautiful and fascinating Japan, wish I could go myself !