New paper by Kwok Lab Kwok Lab. RNA G-quadruplex structure targeting and imaging: recent advances and future directions. bit.ly/45C3AJf

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, out today in Nature Biotechnology: nature.com/articles/s4158…. A short tread! (1/n)

The prototypic crAssphage is a linear phage-plasmid: New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range cell.com/cell-host-micr…

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks doi.org/10.1093/nar/gk…

I hope it is timely and valuable in the context of current global #Chikungunya #virus #outbreaks... A Structural Perspective on the #Alphavirus Life Cycle | Annual Reviews - go.shr.lc/3Un7qiF

This review provides an overview of RNA aptamer-based ribonucleoprotein purifications for both novice and expert researchers to empower ribonucleoprotein research. Dr. Ute Kothe @rnacanadac2r2 UManitoba Science University of Manitoba bit.ly/45Cyj94

Ever struggled with low PNK efficiency on a structured piece of RNA? Sarah solved this problem by using a DNA scaffold to make the 5' end more accessible, improving the efficiency of end labelling. This enabled us to make smFRET measurements on the SARS-CoV-2 pseudoknot 🧬🔴🟢

Dear all, We are starting an exciting project with Clément Carré in Paris, France. A fully funded PhD position is available in my group Vetmeduni Please help us spreading the word! vetmeduni.ac.at/fileadmin/v/z/…

Our August issue is live! nature.com/nchembio/volum… The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex

We are excited to share our latest research on Q-modification in precursor-tRNAs, which just got published in Nature Communications. This was an very exciting and fruitful collaboration with FrancescaTuorto in Heidelberg. nature.com/articles/s4146…

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab Caltech and the Qi Lab UVA: biorxiv.org/content/10.110…

New preprint alert! We developed a covalent small molecule that targets guanines in structured RNAs, guided by the FMN riboswitch structure. In collaboration with Rob Batey biorxiv.org/content/10.110… #RNA #DrugDiscovery #ChemicalBiology

New group leader opportunity John Innes Centre - We're looking for interests in (not limited to) growth and development, environmental/organismal interactions, physiology, signalling, cell biology, biochemical, and modelling approaches jic.ac.uk/vacancies/grou…

GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion nature.com/articles/s4159…

Excited to share our latest work with the bullock lab! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. biorxiv.org/content/10.110…

New online! Structural insights into higher-order natural RNA-only multimers bit.ly/4m6opSt

#Guanidine was known since the 1870s to affect muscle function. Vertebrates have guanidine-sensing #riboswitch RNAs linked to genes relevant to muscle disorders, including some for Ca2+ signaling and others relevant to #ataxia symptoms. Nature Communications nature.com/articles/s4146…

Featured on the cover of Science Magazine, BioEmu Microsoft Research, a deep learning system that rapidly generates diverse protein conformations for accurate insights into protein function. Illustration: N. Burgess/Science; Data: S. Lewis et al., science.org/toc/science/38….

New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07

Disulfide-based dimerization of modified nanobody scaffolds enables higher-order assembly for high-resolution cryo-EM structure determination that is widely applicable to small protein targets nature.com/articles/s4158…