Thrilled to announce our latest work in Cell! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/… (1/5)

Our paper on splicing isoforms in developing human brain is finally out in Science Magazine! So grateful to Luis de la Torre-Ubieta and Michael Gandal for letting me be part of this amazing work. Congrats Ashok Patowary, PhD Pan Zhang Connor Jops! science.org/doi/10.1126/sc…

Today, I'm excited to present the second big chunk of my Ph.D. work. We are building a thorough assessment of the burgeoning field of gene expression forecasting. Something is deeply wrong.🧵 - Preprint: biorxiv.org/content/10.110… - Code: github.com/ekernf01/pertu…

New long post by me: The decline in cancer mortality is about much more than smoking. Many factors — including improvements in diagnosis, medical and surgical innovation, vaccination against cancers — have had a very real impact. scientificdiscovery.dev/p/the-decline-…

Excited to to see our collaboration with GB lab published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome science.org/doi/10.1126/sc…

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors.

In Nature Genetics we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & for myself, expanding my inpatient neuropsychiatry work to the service

Postdoc positions available in my lab Karolinska Institutet - exciting science and fantastic environment. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. shorturl.at/sj2YE

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack & 29,000 panic disorder cases. medrxiv.org/content/10.1... We find 17 variants & evidence that peripheral neurons in eye, lungs & heart are involved in panic & other psychiatric disorders 1/n

Today Arc Institute releases State, our first perturbation prediction AI model and an important step towards our goal of a virtual cell State is designed to learn how to shift cells between states (e.g. “diseased” to “healthy”) using drugs, cytokines, or genetic perturbations

DeepMind just dropped a 106-page paper unveiling AlphaGenome. This single model could completely redefine how we discover disease-causing mutations and drug targets. This is massive. 🧵

🚨 New #preprint alert! We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety" biorxiv.org/content/10.110…

Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in Cell Reports, Faraz K Mardakheh and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." nature nature.com/articles/s4158…

New preprint from our lab led by an amazing team, Celine Vuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome. #brain #singlecell #multiomics #DownSyndrome biorxiv.org/content/10.110…

Today in Cell we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t… 1/10

Congrats to McKnight Foundation 2025 Neurobiology Brain Disorder awardees: Hyejung Won Upasna Sharma Allan-Hermann Pool ZucheroLab Ethan Hughes. Honored to be on the selection committee. So many amazing applicants this year focused on brain disorders.

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵: