Finally out! Congrats! AndHR Silvia Jimeno Pedro M. Martínez García José Terrón-Bautista J. Lieberman and G. Millán Hope we contribute to the idea of supercoiling as a key regulator of genome metabolism, and not just a side-product of DNA transactions. More to come ... cell.com/cell-reports/f…

Happy to share latest work from the lab! nature.com/articles/s4146…

SRSF2 safeguards efficient transcription of DNA damage and repair genes dlvr.it/TFgt5G

New paper with Goran Kokic and Jesper Svejstrup Laboratory in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by diana van den heuvel , Marta Rodríguez-Martínez, Paula van der Meer! cell.com/cell/fulltext/… 1/6

PhD position available in the Jones lab! warwick.ac.uk/fac/cross_fac/… MIBTP programme. Understanding how DNA replication and the nuclear membrane deteriorate with age. With Zita Balklava Aston University Application deadline 16th Jan 2025

🧬 I'm happy to announce that our latest study, "ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping," is now available on bioRxiv! 🧬 Check it out here: biorxiv.org/content/10.110… UC Irvine Rémi Buisson Ambrocio Sanchez Abby Green 🧵🧵🧵

Whilst it is not related to DNA repair or replication, an interesting study I was peripherally involved in is out now Journal of Experimental Medicine. Dominant mutations in ITPR3 cause combined immunodeficiency in humans. Congrats to Alexandra Kreins, the lead PI of this study. rupress.org/jem/article/22…

Great collaborative study just out in Nature Communications about RNF168 regulation by PIN1. nature.com/articles/s4146…

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…

Awesome paper from Steve Jackson Lab and Johannes Walter about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it. nature.com/articles/s4146…

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks dlvr.it/TLZkmH

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1

Delighted to announce that our paper showing the generation of iPSc from a MDS patient & how CEBPA drives disease progression is finally out in Nature Comms! A big thanks to everybody involved & the great collaborators that have made it possible! nature.com/articles/s4146…

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦NatureStructMolBiol⁩ #CryoEM #transcription nature.com/articles/s4159…

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling Cell Reports. Congratulations to first author Antonio Galarreta and to all co-authors. cell.com/cell-reports/f…. #Microscopy #RNAiScreen #Condensates

Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity! nature.com/articles/s4146…