Very excited to share our pre-print and my thesis work on the postnatal development of astrocyte regional heterogeneity, which includes an integrated dataset of >1.4 million single nuclei transcriptomes in mouse and marmoset brains (now available online)! biorxiv.org/content/10.110…

🚨NEW PAPER ALERT 🚨 Our paper just got published in Immunity ! From Munich with 🥨 Check it out here: cell.com/immunity/fullt… Seiji Kaji, Stefan Berghoff, Mikael Simons #apoe #Alzheimers #microglia 1/9

🚨📢 Excited to announce our new paper in Science Advances! We’ve uncovered how Shank3 mutations affect myelination in an autism mouse model and human iPSC-derived OPCs. 🧠💡 Check it out! science.org/doi/10.1126/sc…

New work from Alicia Pietramale that defines in vivo mitochondrial morphometrics and dynamics in microglia. Alicia discovered that mitochondria are rarely present in surveillant or injury-responding processes. biorxiv.org/content/10.110… Dartmouth MCB Graduate Program Integrative Neuroscience at Dartmouth (IND) Dartmouth Arts and Sciences

Important work from Fraser Sim's lab-keep in mind for MS: "Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model" onlinelibrary.wiley.com/doi/10.1002/an…

nature.com/articles/s4146… I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:

My second manuscript from graduate school is now on bioRxiv! We generated a comprehensive scRNA-seq dataset of mouse OPCs from young adult to aged animals with the hope of providing a reference dataset for everyone to dig into! tinyurl.com/aging-opcs

🚨 Cues of trained immunity in macrophages of Multiple Sclerosis patients... Curious to know more? 🔍 Dive into our latest paper showcasing the fantastic work by Jennifer Fransson! 🧾✨ #MultipleSclerosis #TrainedImmunity #OpenAcess Institut du Cerveau - Paris Brain Institute neurology.org/doi/10.1212/NX…

Agreed! That's why I wrote ggpubfigs, a ggplot2 extension that *only colorblind-friendly color palettes. Easily make your figures colorblind-friendly with ggpubfigs! x.com/NKWhiteman/sta…

Our work with Lucas Schirmer in multiple sclerosis (MS) is out today in Nature Neuroscience. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️ nature.com/articles/s4159…

Cool! Learning-associated astrocyte ensembles regulate memory recall nature.com/articles/s4158…

My first-author paper is out today Nature Communications ! We investigated how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in developing myelin and explored nonvesicular lipid transport involved. #lipidtime doi.org/10.1038/s41467… (1/n)

Online now: White matter aging and its impact on brain function dlvr.it/TG94g9

New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. biorxiv.org/content/10.110…

Our 7-year journey on glia-like taste cells is finally published in Cell! We report how the glia-like cells shape sweet adaptation on the tongue. Huge thanks to our lab members, especially Ghayeon & Geehyun, and collaborators Yulong Li Lab. cell.com/cell/fulltext/…

New paper out from the lab! Led by Gustavo Della Flora Nunes and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 nature.com/articles/s4146…

Excited to share our work published this week! Led by myself and world class co-first Gustavo Della Flora Nunes working in the Ethan Hughes in collaboration with Dan Denman: nature.com/articles/s4146…. A short 🧵

Extremely happy to share our manuscript jointly authored by me and the amazing Lindsay Osso ! An awesome collaboration between the Ethan Hughes , denmanlab and Autobahn Therapeutics nature.com/articles/s4146… 🧵

Excited to finally have this published! Out today in Nature Communications, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. nature.com/articles/s4146… 1/3