Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too! Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭 ➡️Cortical silencing results in paradoxical fMRI overconnectivity tinyurl.com/yy269j92 Thread below 1/n

Join neuroscientist Alessandro Gozzi from the Italian Institute of Technology for the next Feindel virtual seminar entitled "Unravelling brain connectopathy with cross-species #fMRI". Register for free here: eventbrite.ca/e/feindel-virt… #neuroscience

#Autism is often associated with an excess of synapses: but how does this trait affect large-scale circuit function? Here's what we found by modelling autism-related pruning deficits across-species🧠🐭 ➡️tinyurl.com/y2yfj74o By Marco Pagani Michael Lombardo & al. Thread 1/n

If you are interested in #fiberphotometry, check out our recent work, led by Cinzia Montinaro in Ferruccio_PhC & Massimo De Vittorio labs, on how the local brain anatomy shapes the volume you can record from! #neuroscience #optogenetics biorxiv.org/content/10.110… 🆎 🐳 Marco Pisanello

fMRI mapping has revealed distinctive "signatures of consciousness" in humans🧠and primates🐵 ➡️Can similar patterns of fMRI signal coordination be identified in lower mammalian species? Here is what we found using rsfMRI in *awake* mice🐁🐭➡️bit.ly/38x9FYN Thread 1/n

Out today in Nature Communications our 🐁+👨work where we show that in #Autism ➡️(mTOR-related) excess of synapses causes aberrant fronto-striatal activity ➡️ this signature can be decoded in human fMRI scans, defining an identifiable autism subtype IIT 1/4 tinyurl.com/265xy8ha

Out today in Current Biology our latest work (tinyurl.com/2p8k83b4) where ➡️we establish robust methods for awake mouse fMRI ➡️reveal an evolutionarily-relevant "fMRI signature of consciousness" in rodents. Many thanks and congrats to Daniel Gutierrez-Barragan & lab! Brief summary below🧵

Excellent commentary by Evelyn of our recent investigation of fMRI dynamics in conscious mice Commentary➡️Consciousness: Mapping the awake mouse brain (tinyurl.com/hnj8am44) Link to original article➡️tinyurl.com/2p8k83b4 Current Biology

How do cortical perturbations affect fMRI connectivity? Not necessarily as one would expect! Our new work Nature Communications shows that cortical inactivation may unexpectedly INCREASE fMRI connectivity! rdcu.be/cHKie 🧵below explains how. Spoiler: δ oscillations are key! 1/n

Task-free fMRI is governed by high-amplitude BOLD coactivations (termed "CAPs"). But how do these patterns emerge and what do they mean? New collaborative work conceived by #Diego_Fasoli and #Stefano_Panzeri provides possible explanations 👉tinyurl.com/2p8un5kp 🧵1/n

Awake whole-brain functional imaging is the new el dorado in our community (fMRI+fUS). Yet, awake datasets (on average) under perform our best anesthetized protocols. I want to identify the protocols and practices that work!

Faculty position alert 📣 Our institute IIT welcomes applicants with an outstanding track-record in Computational Neuroscience. We provide support for salary, start-up budget, and annual running costs. Feel free to reach out for informal inquires 👉tinyurl.com/7ztdnkbn

#Autism affect males more than females, but the mechanisms underlying this sex bias remain elusive. Our new preprint (with Michael Lombardo) describes one of such mechanisms, and the effect it has on brain function and gene transcriptomics. 👉tinyurl.com/nhasuxmj 🧵1/n

I've been sending tons to emails today asking for awake 🐭 functional 🧲 or 🎙️ datasets. If you haven't gotten your email, get in touch!!! #awakerodent #multicenter

fMRI enthusiasts - your ISMRM workshop needs your abstracts. Please help spread the word and mark the date on your calendar. We look forward to seeing you in Padua! ismrm.org/workshops/2023…

The official call for a fully-funded PhD scholarship in my lab is now online at CIMeC UniTrento Application link 👉 lnkd.in/dEJ4GBjS Application Deadline is May 31 Research topic is "Synaptic modulation of functional connectivity" lnkd.in/d5vg2kMg #PhDposition

Previous studies have described evolutionarily relevant fMRI networks in mammals 🐁🐒👨 But how can we relate these networks across species? And is their *dynamic organization* also evolutionarily conserved? Here's what Daniel Gutierrez-Barragan et al found! ➡️tinyurl.com/t9pwst36 🧵1/n

Huge congrats to the incredible @HereCaterina and all coauthors including Elizabeth de Guzman Marco Pagani Thomas Nickl-Jockschat, star collaborators Michael Lombardo, #yuriBozzi and Massimo Pasqualetti. And grateful to @SFARIorg and European Research Council (ERC) for funding this work (a looong time ago - 2016!) 4/4

🚨Preprint Alert🚨 I am so happy to share these main results from my PhD. Thank you so much Zsolt Lenkei for the opportunity and the supervision, Andrea Kliewer for this friendship in life and science, Samuel Le Meur-Diebolt for your trust and unlimited support and all our collaborators

Talk #2 is by Elizabeth de Guzman (Same session, 13:30 pm). Elizabeth used synthetic (optogenetically-generated) brain oscillations to probe the brain rhythms that *causally* sustain fMRI connectivity Spoiler: Regions of the default-mode network show resonance properties🧠! 2/4