“Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants” by Eunju Shin et al. Nature Communications nature.com/articles/s4146…

Proteomics + neurobiology are powerful combo! Here we describe a multimodal (APEX, APMS) and dynamic (stimulation, mutants) PPI analysis for tau that enhances our understanding of both tau molecular biology as well as clinical protein profiles from AD patients.

DHHC enzymes catalyze protein palmitoylation in thousands of substrates. We used a combination of crystallography, computational simulations and biochemistry to present the first structure of a precatalytic complex of human DHHC20 with palmitoyl CoA. pnas.org/content/119/7/…

I would like to thank many friends and colleagues for messages of support on the first day of Russian invasion of #Ukraine! For those, who would like to contribute to the humanitarian effort, please consider donating to British Red Cross 🧡: donate.redcross.org.uk/appeal/ukraine…

new out in Nature: nature.com/articles/s4158…

#OpenCell – Proteome-scale measurements of human protein interactions and localization is now published in Science Magazine. In collaboration with the Chan Zuckerberg Biohub Network we leverage #CRISPR technology and combine ultra-sensitive #proteomics with confocal imaging. science.org/doi/10.1126/sc…

#JBCMethodsMadness Championship is tomorrow at 12:00 p.m. ET! #TeamMassSpec vs. #TeamCryo 🟦🟨Be there or be square🟨🟦

Our paper on sgRNA profiling of #SARSCov2 Oxford Nanopore ARTIC Network genomes using periscope showing lineage specific changes is finally out! We find a striking increase in sgRNA abundance in B.1.1.7 infections and a potential sgRNA for ORF9b! 💥 nature.com/articles/s4200… short 🧵1/3

Dear Boris Johnson, I hear Rwanda is a lovely place to spend your retirement. Ken

Great work Mohamed!

We have several new lectureships available! Sheffield is a great place to live, work and do science. If you or anyone you know want to join us, please get in touch! Please retweet.

So sad to hear the news of the passing of my mnd hero Doddie Weir. I'm sorry to say, how many more warriors die before this stupid government give the 50m they said they would give. I'm absolutely gutted to see my friendly giraffe die. You are the reason for being so positive RIP

Phosphorylation based signalling is still quite understudied despite a general perception that it is well understood. A great study here measuring specificity for human serine/threonine kinases nature.com/articles/s4158…

A BBSRC-funded PhD position is available to investigate how plants shape stress memories. With Mark Collins and Katherine Denby. Please RT and spread the news! For further details, check FindAPhD: findaphd.com/phds/project/w…

Congrats - an incredible resource!

Congratulations to British Mass Spectrometry Society , @PerditaB and everyone involved in making this possible! A much needed investment into UK's mass spectrometry infrastructure. Thank you, Medical Research Council UK Research and Innovation !

You know those times when you come out of a theater and just know that film would win Best Picture…this is the human genetics equivalent. I’m not prone to hyperbole but cannot remember the last time I was this impressed by a genetics manuscript. Congratulations!

🚨New analysis from The Royal Society UK visa costs for researchers: 🫣 21x higher than France (Talent passport for researchers) 😱34x higher than Germany (Scientific visa) 😬Have increased by 126% since 2019 while other countries have made theirs cheaper royalsociety.org/news-resources…

Just look at how the rate of increase in life expectancy has been dropping in this country. And it’s not just since COVID/2020. The decline seemed to start around 2010… weird, that.