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Want to base edit and no PAM in reach? Just create one! "Inception" is a one-shot event based on a canonical target site to create a de novo PAM and a 2nd editing upstream, relaxing steric dependencies. #CRISPR #baseedit with Kaisa Pakari, WittbrodtLab biorxiv.org/content/10.110…

Many many many Congratulations!!!

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

Congrats to my former ⁦Harvard University⁩ bandmate ⁦Carolyn Bertozzi⁩ on her ⁦The Nobel Prize⁩ in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex. news.stanford.edu/2022/10/05/car…

Diversity of perspectives engenders scientific creativity and innovation… the always inspiring Carolyn Bertozzi 🤩

Remove academic age limits on ERC grants - Firma la petizione! chng.it/QfPvBvCW via Change.org Deutschland

Base editors have never been easier to use in zebrafish Marion Rosello nature.com/articles/s4159…

Our latest review on ADAMTS proteoglycanases and thoracic aortopathies is now out on IJMS: mdpi.com/1422-0067/24/1… Congratulations to Marsi for her first publication! BSMB ISMB

Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling Read this #OpenAccess Research Article by Alessio Paolini, Dinara Sharipova, Tim Lange & Salim Abdelilah-Seyfried Seyfried Lab Universität Potsdam: journals.biologists.com/dev/article/15…

4-year funded PhD position in our lab to study ECM remodelling in zebrafish heart morphogenesis - genome editing, live imaging, in silico reconstructions, all in one of the most affordable and outdoorsy UK cities to study in 😍 DM for informal Qs 🫀🐟 tinyurl.com/3tnrphhz

Happy to share our review in Cells & Development on active roles for a dynamic ECM during development. Is it time to alter our general cell-centric description of tissue morphogenesis and make a little space in #DevBio textbooks for the #ECM? doi.org/10.1016/j.cdev…

Our work reveals that in zebrafish embryos, Wnt5b and Ror2 are transported via cytonemes to initiate Wnt-PCP signaling, challenging traditional views on cellular responsiveness based solely on receptor expression nature.com/articles/s4158… Wnt UK LSI Exeter

Early heart development is an incredible and complex process. I recently wrote a review on this for Current Topics in Developmental Biology - the article will eventually sit behind a paywall but you can access it for free via this link until 14th April🫀authors.elsevier.com/a/1if9PFzn7SU0B

🎉 Exciting News! 🎉 I am absolutely thrilled to announce that I've been awarded a HFSP grant to embark on a brand new project decoding the invisibility superpower in fish! Together with Ramialison Lab and Sonke Johnsen we will study the basis for transparency in Danionella

Congratulations to Agatha Ribeiro and all co-authors for their recently published study on egr3! #paperalert 👏👏 science.org/doi/10.1126/sc…

Do not miss our commentary in Nature Cardiovascular Research on the roles of the rare vascular disease-associated CCM proteins in general vascular physiology: doi.org/10.1038/s44161… Leducq Vascular Malformations Network Vascular Biology NAVBO EVBO Max Delbrück Center DZHK Germany Charité - Universitätsmedizin Berlin

New paper alert 📰 Beyond excited to share the latest work from our lab by first author Dorothee Bornhorst at Nature Communications ! nature.com/articles/s4146… The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish