It's funny how people think they can just assert the linear model doesn't work without any argument or evidence like no one has ever thought of this before or looked into it.

"Levin’s limb-regrowth work is still in frogs, with small sample sizes and strict lab conditions. Repeating it in mammals—and then humans—takes years of careful toxicology, dosing and delivery studies" Why it takes years lol. We literally could have 100 labs working on this shit

New work confirming the frustration-decoupling theory of Conscientiousness and extending it to physical work as well as intellectual effort. 1. Work is frustrating. 2. Frustration makes us stop working. 3. Conscientiousness decouples the link of effort to frustration, allowing

I’ve been working with an IVF startup, Herasight, that has already screened hundreds of embryos. Today we come out of stealth with a paper showing that our predictors for 17 diseases — validated within-family — beat the competition, with improved performance in non-Europeans🧵

Happy to say we're coming out of stealth -- Herasight we've screened hundreds of embryos using in-house developed polygenic risk scores that are the most accurate in the field, alongside some other SOTA developments that we'll announce in the coming months. Check out

Great to see this launch of new polygenic scores for IVF embryo selection from the group at Herasight. Why I think this area/team is interesting (and I agreed to be an advisor to the company): 1. From a market perspective, having children is one of the few times that people

This stuff is seriously concerning.

Scott Alexander has written a great article on the burgeoning field of embryo selection, featuring our recently launched company Herasight. Scott has used the technology himself and gives an overview of the field - this is an essential read for anyone curious to learn more.

New Anthropic research: Persona vectors. Language models sometimes go haywire and slip into weird and unsettling personas. Why? In a new paper, we find “persona vectors"—neural activity patterns controlling traits like evil, sycophancy, or hallucination.

✅ Published in nature today, the paper describing the initial whole-genome sequencing analysis of 500,000 UK Biobank participants. nature.com/articles/s4158…

🚨 Our parent-of-origin study is out in nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗nature.com/articles/s4158… Highlights below!

Jonathan Anomaly sits down with philosopher Allen Buchanan to discuss the ethics of polygenic embryo screening.

🚨 My new paper! How can we improve polygenic score (PGS) performance across diverse populations? I benchmarked leading PGS methods across EUR, AFR & EAS ancestries — and found a simple, accurate, and efficient approach. 🔗 tinyurl.com/6cmvxnu2

Causal inference is all the rage. But good descriptive research is vital. This new article lays out an argument for what makes good descriptive research.

Personality genetics is advancing fast. Elliot Tucker-Drob and Dorret Boomsma collect the world's literature here with 5 secure findings: 1. Genetic effects on personality are sizable, summing across hundreds of small genetic variants. 2. Personality genetics drives associations with

Stage IV cancer is a rollercoaster - cliche but true - where one week you are completely non-functional and another you can hike up a large mountain (Mt Baden Powell, 2870m). I'm back in for chemotherapy infusion 3/4 of this round on Tuesday, which will floor me again for

Polygenic screening can be a powerful way for parents to improve their future children’s health, especially if they have a family history of disease. The best way to promote this technology is to help prospective parents understand it, not to pressure them into using it.

The "First Law of Behavioral Genetics" states that all traits are at least partially heritable. But Emily Willoughby and her colleagues found an exception to the Law: beliefs about free will and determinism! Beliefs about fatalism and unpredictability had low heritability (in the

about 1 in 500 men have an XXY karyotype, i.e. two X chromosomes. 75% of them are unaware of this. associations include: - 16x odds of infertility - 5x odds of venous thrombosis - several others Interesting study!

Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion medical events. Including: diagnoses, medications, lab values, procedure Cons: model is not shared (and unlikely will be) arxiv.org/pdf/2508.12104