Pauline Johnson
@paulinej_immi
Immunologist. Scientist. Researcher.
ID: 477275435
29-01-2012 01:13:29
867 Tweet
325 Followers
268 Following
For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…
Excited to share our new story freshly out in Nature Immunology, answering the key question, how do memory B cells (MBC), upon antigen recall, decide to participate in secondary germinal centers (GC) or become plasma cells (PC)? Quite relevant to HIV bnAb vac nature.com/articles/s4159…
Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… Gustavo França
Much of dementia—perhaps half—could be prevented or substantially delayed with attention to 14 modifiable risk factors The Lancet Commission 2024 report thelancet.com/journals/lance… New inclusion of cholesterol and vision loss as risk factors
🧵(1/) I am SO proud of our work finally showing how microbiome and antibiotics sculpt the newborn immune response to be pro-allergic: Microbial intestinal dysbiosis drives long-term allergic susceptibilit... sciencedirect.com/science/articl… CIHR University of British Columbia AllerGen Network Stem Cell Network
SBME and Djavad Mowafaghian Centre for Brain Health are hiring an Assistant Professor (Tenure Track) in Neuro Bioengineering to lead a collaborative and convergent research program at the interface of engineering and molecular/cellular neuroscience. Learn more: bit.ly/3AJTbxB
New report of a nasal vaccine booster provides strong, durable #SARSCoV2 cross-variant protection—preventing infection— compared with shots in non-human primates nature.com/articles/s4159… Nature Immunology