Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology biorxiv.org/content/10.110…

Minted as a Version of Record in January, this study found that in cultured cells, mitochondria maintain temperatures of up to 15°C above their environment adjusting their heat production in the face of physiological stresses. #12DaysOfeLife elifesciences.org/articles/89232…

Can we predict future brain activity in a small vertebrate?🤔 We're releasing ZAPBench⚡️(#ICLR2025 spotlight): a benchmark to forecast activity in a whole vertebrate brain🧠 at single-cell resolution!🐟 70k+ neurons, 3 TB of data & extensive baselines. Connectome is coming! 🧵👇

Thrilled to be part of this exciting project and to collaborate with Prof. Dr. Irina Dudanova's team!

Witness the dynamic interaction of mitochondria (🟢) + lipid droplets (🔴) during fat cell differentiation. The nature of these contacts determines the metabolic signature of the cell

New! Online now: Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin dlvr.it/TJphMr

Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding! #aging #proteostasis cecad.uni-koeln.de/outreach/news/…

Important to celebrate trainee victories: excited to have Holly Merta's paper out in Cell Reports. We use TurboID sub-organelle proteomics to map the ER network. We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. sciencedirect.com/science/articl…

🪰By infusing a virtual fruit fly with #AI, Janelia & Google DeepMind scientists created a computerized insect that can walk & fly just like the real thing➡️ hhmi.news/3Rwop0w 🤖Read more about this work, first published in a #preprint in 2024➡️ hhmi.news/4cGAVUW

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

“Now more than ever, science is essential for addressing complex global issues,” writes UC Berkeley Metabolic Biology professor Ana Paula Arruda. Learn more about her career path—and advice for new scientists—in our spring magazine. nature.berkeley.edu/breakthroughs/…

I just donated to help recover from a devastating fire that destroyed a local farm's essential structures. Every bit counts. Please consider giving or sharing to support their recovery. gofund.me/a59ee620

How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…

Congratulations to UC Berkeley Metabolic Biology professor Ana Paula Arruda and postdoc Alex Inague, who each received multiyear grants from The Pew Trusts to support their research and professional growth. Read more: linkedin.com/pulse/two-nst-…

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/18…

Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases

Look at those beautiful mitochondria (red) surrounding a lipid droplet in a liver cell!

Toxic protein aggregation is a hallmark of Huntington's, ALS, Parkinson's… and enhancing the cell’s natural protein-clearing machinery is a promising therapeutic avenue. David Vilchez at CECAD/University of Cologne studies how protein homeostasis breaks down with age and how

Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs.7…

🚨We’re getting down to the wire!🚨 We need 75 more gifts to unlock the final $57,000 in #CalBigGive matching funds. Every gift—no matter the size—helps us reach our goal. Join our final push by making your gift before 9 pm: givingday.berkeley.edu/giving-day/108…