Today is a special day. Our multi-year study led by an AMAZING group of scientists Mariko Takahashi, Harrison Chong and Siwen Zhang comes out Cell. DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Check it out here: authors.elsevier.com/a/1izTCL7PXqQHi.

Congrats to Prof. Benjamin Cravatt for receiving the 2024 Bristol Myers Squibb Award for Enzyme Chemistry from the ACS Biochem and ChemBio. His work in activity-based protein profiling revolutionizes treatments for neurological disorders and cancer. 🎉🌟 More at: ow.ly/p6KL50RyOwU

📢 Our latest paper is out in Cell! Led by the multi-talented Xinhe Zheng, we accelerated AAV-based gene delivery to 2 days & enabled in vivo CRISPR screens with single cell-level readout, a leap from existing capabilities 🤯 How does it work? (1/8)

5a-reductase-3 is really not a 5a-reductase. There are only two. A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis: Cell cell.com/cell/fulltext/…

1/Sharing a new セルメタ paper from Zheng Wu, showing that cancer cells need purine salvage to grow during ETC inhibition. This allows them to tolerate suppression of de novo purine synthesis, which requires the ETC. -RJD sciencedirect.com/science/articl…

Min Zhu et al. show that somatic mutations in PKD1 (POLYCYSTIN1) are selected for in chronically damaged livers because they promote hepatocyte clone fitness without driving carcinogenesis. This shows that some somatic mutations are beneficial. (1/8) cell.com/cell-metabolis…

Thrilled to finally share an amazing discovery made during my PhD Kivanc Birsoy's lab. We found that glycosphingolipids in the plasma membrane of cancer cells impact how sensitive they are to immune cells. nature.com/articles/s4158…

Excited to share a key part of my postdoctoral work in the Cravatt lab at @ScrippsResearch, published today in Nature Chemistry! Huge thanks to collaborators Bruno Melillo, Rachel Hayward, Vividion Therapeutics, and all coauthors.

1/Out today @nature, a paper from Divya Bezwada and DeBerardinis Lab Children’s Research Institute at UT Southwestern about metabolism in human clear cell renal cell carcinoma (ccRCC). Divya identified an unexpected metabolic change that allows these tumors to metastasize. 🧵below.-RJD nature.com/articles/s4158…

Our study on sex differences in Xp11 translocation renal cell carcinoma is out Cell! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @danafarbernews bit.ly/4dtpNtP 🧵1/

Congrats to Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, on receiving the 2024 Heinrich Wieland Prize. His work on disease-causing proteins and activity-based protein profiling is advancing drug discovery. ow.ly/Jgze50T4xUE

Out in nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…