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Regulators in the U.K. on Thursday approved a CRISPR-based medicine to treat both sickle cell disease and beta thalassemia, making it the world’s first therapy based on the revolutionary gene-editing… trib.al/9wX7q6C

Click editor plasmids now available on Addgene addgene.org/browse/article… 🧬🖱️ Looking forward to feedback from the community on how well click editing works in your hands! Joana Ferreira da Silva Connor Tou Emily Madden King Madeline Eller Linyuan David Rufino-Ramos

Delighted to share that our work to develop a base editor-mediated genetic treatment for SMA is now published in Nature Biomedical Engineering 💉💉🧬🎉 Congrats 👏 to @Christiano_RRA who led this work & all co-authors CGM at MGH @MGH_RI MGH Neurology MGH Pathology Harvard Medical School 🧵 nature.com/articles/s4155…

Thanks to Jonathan D. Grinstein, PhD GEN Biotechnology for featuring our recent work on developing click editors Joana Ferreira da Silva Connor Tou & complementary work from ErikSontheimerLab Wen Xue on DPEs! 🙏🧬

Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

🎉 We made a graphing tool for biological data. And it's free for academics! 📊🧬 Make publication-quality figures in under a minute. No more fiddling with Excel, Prism, ggplot, and PowerPoint. Here's using Sphinx Bio for graphing qPCR data.

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

Congrats to Matt Durrant Nicholas Perry Patrick Hsu hnisimasu and colleagues on their bridge recombinase works! Excited to see how this technology progresses. 🧬 Ben Kleinstiver and I highlight their two papers in nature Nature News & Views: nature.com/articles/d4158…

Here it is our latest review work on the potential of EVs and VLPs for the delivery of genome editing technologies. drive.google.com/file/d/1EL8RLv… Congrats to all authors @KevinLeandro84 Koen Breyne Pedro Perdigão Emilio Di Ianni ruinobre Ben Kleinstiver LAlmeida Lab

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

The 2024 #NobelPrize in Physiology or Medicine focuses on the discovery of a vital regulatory mechanism used in cells to control gene activity. Genetic information flows from DNA to messenger RNA (mRNA), via a process called transcription, and then on to the cellular machinery

Good at herding nerds? 🤓🧑‍🔬🔬🧬 We're hiring a lab manager! Looking for a dynamic team member that will play a major organizational role in our group, from managing inventories, organizing the lab, maintaining equipment, onboarding and training new lab members, updating our

Check out our bioRxiv describing our efforts to treat a severe vascular disease 🫀: 1️⃣ Optimization of a target-specific base editor🧬 2⃣ A *must avoid* bystander edit prevalent with WT SpCas9 BEs! 🙅‍♂️😱 3⃣ Substantial extension of lifespan following in vivo base

Thank you to the amazing team for this incredible work! Check it out here: sciencedirect.com/science/articl… Katia Maalouf, PhD Edwina Abou Haidar, MBBS, MSc David Rufino-Ramos Ben Kleinstiver Christine Vaine Cristopher Bragg 🏳️‍🌈

🔬 New research on DYT1 dystonia! Congrats to Koen Breyne and team Katia Maalouf, PhD on developing a SaCas9-KKH gene editing approach that selectively targets the dGAG mutation in TOR1A while preserving the wild-type allele. Using exRNA from EVs & plasma, AAV-mediated editing was

Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥 We're hiring graduating seniors who are seeking ~2 years of post-bac research experience. If you're interested in gaining experience in next gen medicines, please reach

So excited to share our new paper out today in nature. We repurposed R2 retrotransposons to create STITCHR, a tool that can make diverse edits in mammalian genomes including scarless multi-kilobase scale insertions nature.com/articles/s4158…

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ Rachel Silverstein CGM at MGH @MGH_RI MassGeneral News Harvard Medical School nature.com/articles/s4158…