Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species biorxiv.org/cgi/content/sh… #biorxiv_evobio

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB European Research Council (ERC)

Online Now: m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiation dlvr.it/TFvKLm

Dr Amanda Moehring & team generated #Drosophila strains where tRNAs mistranslate serine at either valine or threonine codons. In #G3journal, explore how these mistranslations can have a negative or positive effect on lifespan depending on the sex of the fly: bit.ly/3A6q3ka

論文紹介 34日目 ショウジョウバエの精液に含まれるタンパク質ははやく進化することが知られていますが、コード領域はあまり変化していないそうです。 この論文では、精液に含まれるタンパク質であるAcpのプロモーターが急速に進化し、発現も変化していることを示しました。 biorxiv.org/content/10.110…

Yes, polygenic sex determination is a thing! dlvr.it/TG1nlQ

論文紹介 44日目 これは癌細胞におけるextrachsomosomal DNA (ecDNA)について調べた論文です。かなりのサンプル数を用いて、癌細胞の種類ごとにどんなecDNAがあるか調べています。 染色体に含まれていないDNAを今まで認識していなかったので、とても面白かったです！ nature.com/articles/s4158…

Excited to see our LARP1 manuscript published at The EMBO Journal. We show that LARP1 directly binds non-translating ribosomes and TOP mRNAs. An excellent collaboration with the Jingdong Cheng lab! embopress.org/doi/full/10.10…

Congrats to our colleague Qin Peng on the development of a m6A live-cell imaging method. Glad to have helped out on this work. science.org/doi/10.1126/sc…

Birmingham covered in white after a successful PhD viva defence by ⁦David McQuarrie⁩ and fun evening with ⁦@MatthiasSoller⁩ lab. Congratulations!

Coacervate-pore complexes for selective molecular transport and dynamic reconfiguration nature.com/articles/s4146…

DOA/CLK2 phosphorylates Fl(2)d/WTAP to enhance m6A mRNA methyltransferase complex activity biorxiv.org/cgi/content/sh… #biorxiv_genetic

DOA/CLK2 phosphorylates Fl(2)d/WTAP to enhance m6A mRNA methyltransferase complex activity biorxiv.org/content/10.110…

Profound synthetic lethality between SMARCAL1 and FANCM dlvr.it/TGcsSD

New publication from Castello Lab and @FranklinSystems in Molecular Cell 🚨🚨🚨! We discover a group of nuclear #RBPs that travel to the cytoplasm to inhibit #virus #infection. We discover a novel #RNA mediated antiviral mechanism mediated by the U2snRNP cell.com/molecular-cell…

NiCo is out! Our new algorithm for spatial transcriptome data analysis predicts the crosstalk of cell types co-localized in tissue niches and sheds light on the downstream effects of cell-cell interactions by inferring covarying gene programs. nature.com/articles/s4146…

Mapping Targetable Sites on the Human Surfaceome for the Design of Novel Binders 1. A groundbreaking study maps the human surfaceome, identifying 4,500 targetable sites across 2,886 cell-surface proteins. This resource unlocks new therapeutic opportunities for precision

博士課程卒業後の進路とか考えるためにも、意義のあることだった気がします。 第2クールの100日を終えて、一番すごかったと思うのはこの論文です。エンハンサーへの転写因子の結合がこんな制御を受けていた、というのはすごく衝撃的でした！こういう研究もしてみたいです！ nature.com/articles/s4158…

McQuarrie, D. W. J., Alizada, A., Nicholson, B. C., Soller, M. (2024). Rapid evolution of promoters from germline-specifically expressed genes including transposon silencing factors. BMC Genomics, 25(1):678 bmcgenomics.biomedcentral.com/articles/10.11…