Good morning #Medtwitter! Today #Scientissimum would like to show you an interesting #ophthalmology case of removing 23 contact lenses from they eyes. Elderly people who are prone to dementia should be very careful with contact lenses and must be always supervised. Perhaps it’s a

Slow death: misfolded tau accumulating in pyramidal neurons of the temporal neocortex in a monkey model of #Alzheimers. Markers: 🔵dapi🟣neun🟡pTau S422🔴ThioS. #neuroscience ZEISS Microscopy #sciart

#Alzheimers: I thought a lot before sharing this photo because it still impacts me. It's almost a philosophical question, where did the brain tissue go? The holes are not artifacts; they result from extensive inflammation and neuron death. Markers: 🔵pTau (AT8)🟣(Iba1)🟡TREM2

Colorful death: the image below is from our #Alzheimer monkey model and shows neurons in different stages of cell death. Healthy cells in blue only. Markers: dapi (light🔵), pTau S422 (🔴), AT8 (🟢), neun (dark🔵). ZEISS Microscopy #neuroscience #FluorescenceFriday

Una Argentina distinta es imposible con los mismos de siempre!🇦🇷♥️ Se agradece Rt🔃 y difusión #Milei2023 #MileiVillarruel2023 Javier Milei

Cerebral amyloid angiopathy: amyloid deposits 🟡 on the walls of blood vessels, a process occurring with aging and #Alzheimers. Notice the reactive astrocytes 🟣 around the blood vessel and, probably, the disrupted blood-brain barrier. Dapi🔵 #neuroscience ZEISS Microscopy

APOE4 does more than increase your risk of late-onset dementia. 🧵👇 /1

Bad news in #Alzheimer research.. #solanezumab, a drug targeting monomeric amyloid-β species, did not slow cognitive decline in patients with preclinical Alzheimer's in a large cohort of patients. nejm.org/doi/full/10.10…

🧠 Apraxia: Dificultad para ejecutar movimientos coordinados, incluso cuando la persona tiene la destreza y la intención de hacerlos Caso: 👨🏻 69a ✅ parkinsonismo + deterioro cognitivo 🎥 apraxia ideomotora (Bajo comando, no logra ponerse sus gafas)

ESTE VIDEO ES TREMENDO ¡Cuanta Historia! ¡Cuantos recuerdos! El album de una gesta de libertad como nunca se vio. Grande Gabriel te mandaste un videazo.

Brexpiprazole 2 or 3 mg reduced agitation in Alzheimer dementia and was generally well tolerated over 12 weeks. ja.ma/46ZB7ed

A zoom in the Dentate Gyrus (DG), a region in the mammalian hippocampus that is one of the few sites in the brain for continuous generation of new neurons across lifetime, or neurogenesis! Mature neurons with their long extensions can be seen in cyan 🔵, while immature, newborn

Dying neurons accumulating phospho-tau in #Alzheimer Why phosphorylated tau can be harmful? Because it accumulates inside the neuron, disrupting the microtubule system and impairing axonal transport and synaptic activity. The image below from our monkey model of Alzheimer shows

Every #COVID infection is a risk for the brain because: 1- Ace2 receptor (entry receptor for SARS-Cov-2 in cells) is highly expressed in all blood vessels, including cerebral ones. 2- The virus arriving in the brain will cause a mess. Even if you don't look at infected cells,