I think about this cartoon a lot.

Today's PUNCH Cartoon Classic. A breakfast lesson in economics. ‘When Daddy tells you how much he’s WORTH, it means that’s how much he HAS. Daddy as such has practically no market value’ Bud Handelsman 1991 #finance #financial #women #economists #parents #children #theory

UK Coal xkcd.com/2992

Register errors in PDB depositions IUCrJ doi.org/10.1107/S20522… Inst of Systems, Molecular & Integrative Biology University of Liverpool News Diamond Light Source Chemistry at York YSBL EMBL Hamburg Rutherford Appleton Laboratory Biotechnology and Biological Sciences Research #deeplearning #registererror #ProteinDataBank #PDB #structurevalidation #AlphaFold2 IUCr #openaccess

Using deep-learning predictions reveals a large number of register errors in PDB depositions IUCrJ 1. This study uncovers thousands of likely sequence-register errors in PDB depositions, using deep-learning methods such as AlphaFold2 to identify inconsistencies between residue

Deep learning tidies up PDB errors. I love that if there’s enough signal, you can use it to pick out the noise in the training data. Very cool use of AlohaFold2. Pairs nicely with this one showing AlphaFold2 is actually useful for drug discovery: biorxiv.org/content/10.110…

Reminders

Coming soon to a town near you, while our leaders serve billionaire psychopaths & the media distracts us with inanity & bile.

Poorest households gain most, wealthiest pay most in the Budget - Treasury impact assessment.

AlphaFold 2, but not AlphaFold 3, Predicts Confident but Unrealistic Beta-Solenoid Structures for Repeat Proteins • This study investigates AlphaFold 2’s (AF2) tendency to predict high-confidence yet biologically implausible β-solenoid structures for artificial repeat

Thanks to this valuable account for a useful and speedy (<3 h!) summary of our latest work, a team effort led by talented MSc student Olivia Pratt

I've never received so many prayers from atheists.

If ever we needed a laugh it was now, so I am giving away three free copies of my new paperback - signed and dedicated to you or anyone of your choosing. Makes an excellent cheapskate Christmas present. Just retweet this message and I will pick three at random...

This was a mistake. It would have been a powerful statement having somebody there representing the Axis forces.

How many of the PDB models that were solved using experimental phasing could have been solved by molecular replacement using models obtained from AlphaFold? Structural Biology IUCr #MolecularReplacement #AlphaFold2 #ComputationalMethods doi.org/10.1107/S20597…

ABCFold: Easier Running and Comparison of AlphaFold 3, Boltz-1, and Chai-1 - Structural biology has seen a revolution with deep learning-based protein structure predictors like AlphaFold 3, Boltz-1, and Chai-1. However, running and comparing these models efficiently remains a

CASP is getting cut by NIH... 😢 (Anyone with extra funds wanna help support perhaps the most important competition of the century?) science.org/content/articl…