Ok, I am going to try to explain all of chemistry in a short thread on twitter. It will be oversimplified, ahistorical, and wrong in interesting ways, but I like it. Don't hate - you can still confuse students will the details later.

Amazing work combining mutational scanning and structural biology to tease out functions of a key scaffolding protein! Congratulations Jason Kwon and the whole team!

We now welcome proteolysis-targeting antibodies (PROTABs) as degraders of cell surface receptors. nature nature.com/articles/s4158…

Balance is needed when discussing academic careers *both the good and the bad* nature.com/articles/d4158…

Check out our preprint on design and application of Transcriptional/Epigenetic Chemical Inducers of Proximity (TCIPs), to rewire cancer drivers and activate apoptosis. doi.org/10.1101/2022.1… The concept was to hijack a cancer driver, and reroute it to activate cell death.

Our Pre-print is out, showing that FDX1 is an essential upstream regulator of protein lipoylation in human cells. This is mediated through direct binding of FDX1 to the lipoylating enzyme LIAS and not through Fe-S cluster regulation. BroadCancerIDWall biorxiv.org/cgi/content/sh…

We have reopened the call for 1 of 2 postdocs in the Nwosu Lab. New deadline is Jan 31. Please kindly RT. In the spirit of the new year, those who applied in 2023 and believe their situation have changed should feel free to send me their updates directly. academicjobsonline.org/ajo/jobs/26453

Looking for a #Postdoctoral Researcher to join the newly established Tsvetkov lab at the BIDMC Cancer Center , BIDMC Pathology to engage in cutting-edge science exploring questions at the intersection of metabolism, metal and cancer biology. Please reach out if interested and retweet 🙏

The goal of teaching should not be to help the students learn how to memorize and spit out information under academic pressure. 🧠 The purpose of teaching is to inspire the desire for learning in them and make them able to think, understand, and question.

Happy to post this study on a new method for tryptophan labeling and its use to identify cation-pi interactions led by Xiao Shaw Xie and Patrick with Toste Group College of Chemistry UC Berkeley MCB in nature ! nature.com/articles/s4158… 1/n

Amazing new method for identifying substrates (both endo- and drug-induced-neo) of E3 ligases from Hubert Huang! Congrats!

We have a postdoc position available for a very cool collaborative project! Synthetic chemistry expertise is a must! Unfortunately due to the funding source, this position is only available to US citizens or permanent residents. Please share and reach out if interested!