(Near) mode collapse can be a feature, not a bug! Intentional overfitting can be strategic to improve sample efficiency for generative molecular design! We release Saturn 🪐, which features the first application of the Mamba architecture for molecular design. (1/5)

After months of procrastination, I am starting Batch Effect! It's a newsletter on the latest Cancer Research under the lens of Computational Biology and Spatial Omics. In this first post, I shared why I chose this name. Subscribe, it's free! batcheffect.com/p/welcome-to-b…

Weekend project: Comparing ESM3 from EvolutionaryScale to ESM2 and inv_cov. The ultimate test of a protein language models is how well the pairwise dependencies it learns correlate to structure. (1/8)

Finally, a big piece of my PhD project is out! Special thanks to the super team Oriol Artime Samir Suweis Manlio De Domenico

Ever wondered how many amino acids you can mutate to alanine and AlphaFold2 still predicts same structure? 🤔For denovo design Top7 (1QYS), single-sequence mode, it's 60%. (1/2)

De novo protein design is great, but nature has millions of proteins- why not repurpose them? Introducing Raygun, a new approach to protein design. It allows you to miniaturize, magnify or modify any protein. We synthesized miniaturized variants of eGFP and mCherry! 1/

L’UNICO paese nel MONDO dove il ministro della cultura va in esclusiva sulla prima rete nazionale a dire che ha un’amante, ma chi ci batte diosanto

Really impressive work from Together AI! Apparently you can distill large transformer models like Llama3.1 8B into a faster and less memory intensive Mamba model without loss in performance! x.com/togethercomput…