Incredible cell states emerging through interactions (over time!) in stroma-rich pancreatic cancer tumoroids! Our first venture into cancer organoids, huge potential. Congrats Ryo Okuda, Bruno Gjeta, Doris Popovic, Taniguichi lab, Treutlein lab biorxiv.org/content/10.110…

It's out! elifesciences.org/articles/69745 Fun to think about nuclei as mobile processors in the many headed slime mold, Physarum polycephalum! Creative work by Tobias , @nicoschramma, Cristina, Karen Alim, Treutlein lab. Super constructive reviewers/editor, Great experience with eLife - the journal!

Are you interested in cancer organoids/tumoroids and their application in drug discovery and development as well as in personalized medicine? Check out this open postdoctoral position at the Roche Institute for Translational Bioengineering (ITB)! careers.roche.com/global/en/job/…

New Microcourse! An introduction to lateral and axial chromatic shifts, which may compromise the accuracy of your measurements - particularly co-localization. Enjoy! youtu.be/nNZJw0kgzdg

Our paper is out today in Science Magazine, I’m stoked OpenCellCZB ! Check out opencell.czbiohub.org: CRISPR tagging + 3D live imaging + IP mass spec to map the human proteome. science.org/doi/10.1126/sc… 👇 tweetorial from our 2021 pre-print.

Super happy to see DaXi -- the lab's first major microscope design published in Nature Methods . Bin Yang put a lot of work into it with help from many including Merlin Lange Jordão Bragantini Alfred Millett-Sikking Andrew York and many more

#preprint🚨 Overwhelmed when choosing #BioImageAnalysis software? Read our Hitchhiker's Guide🥾 Feedback❤️ly welcome! Big thanks to the team😃Elnaz Fazeli David Legland - Dr Siân Culley Ilya Belevich Eija Jokitalo Martin Schorb Anna Klemm Christian Tischer arxiv.org/abs/2204.07547

Wow, this incredible from Hayashi, Okubo, Kudo, Nishida and colleagues! Human PSC-derived 3D lacrimal organoids: nature.com/articles/s4158…

A bispecific #antibody which distinguishes #cancer cells from healthy cells, doesn't care about #KRAS mutations & was developed entirely on human cancer #organoids. In 3 years from drawing board to clinic. Congrats to all collaborators. Read: rdcu.be/cL4xS

Please RT: I am looking for a 👩‍🎓master's student 👨‍🎓 to join me in a new project: Organoids🧠 + Light Sheet Microscopy🔬. Actually building an LSM. If you know of any good student (in Europe 🌍) that is looking for a thesis (6 months, paid), please fwd them the info. Thanks!!

UPDATE: we are getting ready for a light sheet extravaganza. We are still accepting applications from 👨‍🎓master's students 👩‍🎓 to join us in this project. Loïc A. Royer 💻🔬⚗️ Florian Jug Reto Fiolka Robert Haase Martin Weigert (maweigert.bsky.social) maybe you know of interested applicants?

UPDATE - 🚨 Job opportunity 🚨: good news! if you are a scientist that just** obtained your Diploma/Master's degree, you can also apply for this position. **Within the past 12 months and EU citizen.

Building hardware is hard, sharing design is even harder. We discuss computer-assisted design, why it is necessary, and how sharing your designs can be smoother @nvladimus @ReynaudEmmanuel Dr Caroline Müllenbroich Benedict Diederich Richard Bowman Julian Stirling 🔬🛠️🧑‍🔧 nature.com/articles/s4159… 1/N

An automated multi-scale 3D imaging platform enables both organoid culture and high-content imaging on a single instrument. nature.com/articles/s4159… Viasnoff's lab Anne Beghin

If you would have asked me yesterday, my answer would have been probably hundreds of Pico-Newtons. The fact that you only need ~30 pN to remove a tubulin subunit from the lattice of a MT is mind blowing to me🤯. But it makes sense in the intracellular context.🤔cool!!

This is Incredible! The Institute of Human Biology (IHB) debuted today to the world. The IHB will certainly disrupt the complex in-vitro model's field, contributing to fundamental, translational, and industrial discoveries and developments. I am so proud to be part of this.

Today we announce Roche's Institute of Human Biology in Basel, a bridge between academia and industry. #TeamIHB will develop and validate #organoid technology for every step of drug development at pRED & beyond to improve patient outcomes. institutehumanbiology.com Institute of Human Biology