The GLP-1 family of drugs have exceeded all expectations, beyond diabetes and obesity. Now there's a pre-clinical GLP-1 and NMDA dual receptor drug with many enhanced features that could prove to be another step forward nature nature.com/articles/d4158… nature.com/articles/s4158…

Online Now: mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway dlvr.it/T7HyQP

It's official! Excited to be co-organizing the FASEB conference on “Ferroptosis, Oxidative Stress, and Lipid Metabolism: From Mechanisms to Therapy” w/ Scott Dixon @SJD956 !! Next summer July 27-31 2025! Save the date. More details coming soon. 😀 #Ferroptosis #LipidTime

Happy to share our new paper in print today in Science Advances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at Van Andel Institute (VAI) and Agios. science.org/doi/10.1126/sc…

Everything you've ever wanted to know about #Ferroptosis in Health and Disease! Massive review from many in the field. Happy to have contributed and huge thank you for the leadership from Carsten Berndt / Marcus Conrad The Conrad Lab. 🙂 doi.org/10.1016/j.redo…

A thread to understand the impact of this groundbreaking publication. @nature

REVIEW | Nguyen & Corvera (UMassDiabetes) The authors review changes that occur in adipose tissue during #aging, discuss potential mechanisms by which these changes impact metabolism, immunity & longevity, & highlight therapeutic opportunities. nature.com/articles/s4225…

Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis #diabetes Nature Communications nature.com/articles/s4146…

Gut microbial alterations in arginine metabolism determine bone mechanical adaptation dlvr.it/T7z2qV

Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating dlvr.it/T7zZ8h

New preprint w/ Ana Paula Arruda! Tour de force from grad student extraordinaire Alyssa Mathiowetz! >20 CRISPR screens enabled the discovery of a key role for CLCC1 in hepatic neutral lipid flux and nuclear pore complex assembly. Many surprises! #LipidDroplets 1/3 biorxiv.org/content/10.110…

ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response nature.com/articles/s4225… Congrats to Ayelet Erez & teams, as always, a groundbreaking paper!

Kudos to these STRA6 researchers! RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway. onlinelibrary.wiley.com/doi/pdf/10.100…

This is one of our most popular cartoons which we're sharing for the end of Pride Month, we've also got some new pride cartoons which we'll share next month because we love pride all the time 🏳️‍🌈🏳️‍⚧️ #PrideMonth #Pride

RESEARCH | J. Adkins, S. Bodine et al. (#MoTrPAC; Pacific Northwest National Laboratory, OMRF): Using a multi-omics approach, the drivers of sexual dimorphism in the adipose tissue from sedentary & trained rats is examined, providing a #resource for adipose tissue research🏅 nature.com/articles/s4225…

I feel terribly sorry for the loss of such a brilliant scientist and wonderful person. He will be deeply missed.

Research| Elrod and colleagues reveal the role of ATP-citrate lyase (ACLY) in #myofibroblast differentiation and cardiac #fibrosis. doi.org/10.1038/s44161… 👉 rdcu.be/dMQr2

When you're stupid, you think you know everything, without questioning and when you're intelligent, you question everything you think you know.

Very grateful for this nice project with Christine Kusminski, Diego Perez-Tilve, Richard DiMarchi, Matthias Tschöp and Phil Scherer doi.org/10.1016/j.cell…

Very excited to share our latest paper out today Nature Metabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies. dlvr.it/TCjPl6