🔥New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Two new figures compared to the pre-print, with more in vivo and sequential mutagenesis data. sciencedirect.com/science/articl…

Dasatinib-Resistant Universal CAR-T cells Proliferate in the Presence of Host Immune Cells and Exhibit Antitumor Activity dlvr.it/TJHyS9 #genetherapy #celltherapy

🚨New Blood issue out now featuring: Review: CAR therapy for AML - current challenges and novel strategies ow.ly/kikt50VhlL0

A machine learning approach for the rapid identification of measurable residual disease in acute myeloid leukemia haematologica.org/article/downlo…

Expert recommendations on using MRD in #ALL now out in Blood Advances. ClonoSEQ (NGS MRD) is superior to other MRD methods and should guide decisions about CAR T-cells or SCT MD Anderson Cancer Center #Leukemia doi.org/10.1182/blooda… #leusm

CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant nature.com/articles/s4301…

Dr. Ajay Major, MD, MBA CU Lymphoma Program (as well as incoming CU Anschutz Division of Hematology lymphoma faculty Dr. Cassandra Duarte) contributed to a large study of patients with Hodgkin lymphoma refractory or intolerant to BV and checkpoint inhibitors. #lymsm cc Timothy Voorhees, MD, MSCR

Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients NEJM Evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.105…

CONGRESS | #EBMT25 The EBMT | PRESENTATION Everett Meyer, Stanford Medicine, shares results from the phase III Precision trial (NCT05316701) comparing orca-T with standard-of-care allograft with tacrolimus/methotrexate in patients with AML, ALL, MDS, or MPAL. The trial met its primary

Very excited to share our latest research article published with Springer Nature in Nature Communications. We show that in early #MDS, NK cells share mutations with the malignant clones, becoming dysfunctional and failing to eliminate aberrant stem cells. This leads to immune evasion and

11% patients diagnosed with ITP carried diagnostic grade variants for inherited thrombocytopenia or primary immunodeficiency. ow.ly/Zb3z50VxvTx #plateletsandthrombopoiesis

#Myeloma Paper of the Day: Myeloma with 1q gain/amplification exhibits reduced CD38 expression via interleukin-6 receptor over-expression, and inhibition of the IL-6/JAK/STAT pathway by treatment w/ ruxolitinib or tocilizumab restores CD38 levels: pubmed.ncbi.nlm.nih.gov/40259818/. #mmsm

Review Annual Reviews Molecular Mechanisms Governing CD8 T Cell Differentiation and Checkpoint Inhibitor Response in Cancer annualreviews.org/content/journa… 1, and 1

#Hematology Interim PET after 4 cycles predicts outcome in histomolecularly confirmed primary mediastinal B-cell #lymphoma #PMBCL # lymsm ashpublications.org/bloodadvances/…

A new epigenetic clock —DNAmIC—outperforms others for identifying risk of all-cause mortality, and linked with lifestyle and immune system factors Nature Aging nature.com/articles/s4358…

🚨 NEWS 🚨 The European Commission approves brentuximab vedotin in combination with ECADD (BrECADD) for the treatment of newly diagnosed patients with Stage IIb/III/IV Hodgkin lymphoma. Learn more: loom.ly/Ka90HRc #lymphoma #lymsm #MedNews

TP53 mutations are associated with CD19− relapse and inferior outcomes after blinatumomab in adults with ALL | Blood Advances | American Society of Hematology ashpublications.org/bloodadvances/…

Most genetic variants are assumed to influence disease risk by effects on gene expression. While most variants can affect the expression of multiple genes, existing methods map a single gene at a time. Clustering the expression of neighboring genes can improve eQTL discovery👇

📣 Cell developmental state matters in B-ALL. Our study out today in ⁦Nature Cancer⁩: Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features | Nature Cancer nature.com/articles/s4301…

This week we publish in Nature Biotechnology "High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase". In this work, we show that both nucleotide and context specificity of deaminases can be reprogrammed by hotspot-focused directed evolution 1/n