Plasmids are now available from Addgene !

🧬 New in Nature: STITCHR is a programmable, scarless RNA-templated integration system It fuses site-specific retrotransposons to Cas9 nickase to install payloads from 1 bp to 12.7 kb - no DSBs, no scarring. Let’s break down what it is and how it compares to Tessera, $PRME, and

Happy to announce that our paper on the cryo-EM structures of CRISPR-Cas13 and REPAIR has been published in NSMB! Congratulations, Junichiro! nature.com/articles/s4159…

In a new study, researchers from Mass General Brigham and colleagues showed that a new gene editing tool could help treat disease with multiple mutations. The study was published in nature. Read more: massgeneralbrigham.org/en/about/newsr… Jonathan Gootenberg Omar Abudayyeh

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ Rachel Silverstein CGM at MGH @MGH_RI MassGeneral News Harvard Medical School nature.com/articles/s4158…

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…