What is a pancreatic beta cell? Sounds simple? As many scientists are trying to make beta cells to treat Type 1 diabetes, a better working definition is increasingly important. @KlausKaestner and colleagues define it in a Molecular Metabolism review sciencedirect.com/science/articl…

Though we strobed That we came in peace, He was already at war. We have battled hard to be. Nothing— Nothing— Can keep you safe. Silence least of all. Look alive, everyone. May such a prayer, A people, A peace, A promise, Be ours. Be right & radiant & real.

Well, besides the fact that it happened at a Black protest. That’s EXACTLY what the lynchers in Memphis said. That’s what Daley said. That’s what J Edgar Hoover said. That’s what the troopers in Selma said. They will NEVER SAY it’s about race. It’s an American tradition

Looking forward to Keystone Symposia Organoids as Tools for Fundamental Discovery and Translation Jason Spence Sheila Chari Mellisa Walford little Treutlein lab

Cabrera et al. report that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit 1st phase glucose-stimulated insulin secretion. jbc.org/article/S0021-…

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at satijalab.org/scgd. Please RT/spread the word!

Great Twitter summary and interesting data. Congrats !

Single cell transcriptomic and spatial landscapes of the developing human pancreas biorxiv.org/content/10.110…

The scvi-tools manuscript is now out in Nature Biotechnology! In this thread I describe a bit about what scvi-tools can do for you. nature.com/articles/s4158…

If you say B cells aren’t pathogenic in T1D, read this fist. Marginal zone B cells acquire dendritic cell functions by trogocytosis science.org/doi/10.1126/sc…

Mutating over 2,000 transcription factor binding motifs during early neural differentiation finds key drivers and regulatory grammar for this process. Great work by Anat Kreimer 💔, @TalAshuach, Taka Inoue and others in collaboration with Nir Yosef! nature.com/articles/s4146…

More than deserved !!! Congrats ❤️

Upcoming Workshop: Beta Cell Replacement Therapies A JDRF-NIH-FDA co-organized workshop on beta cell replacement is taking place on May 18-19, 2022. Hybrid Meeting on NIH campus & zoom Registration deadline: May 10 Learn more at: tinyurl.com/beta-may

Exciting new pub ...Probably the largest long term cohort analysis since the citr report 10 years ago. To inform the next generation of beta cell replacement with sc-Islets .... thelancet.com/pdfs/journals/…

🧵1/ Today, my first first-authored paper was published online in Diabetologia 😄 You can read the paper here at doi.org/10.1007/s00125… and fully access our dataset as a web app at lynnlab.shinyapps.io/Human_Islet_At… Read on for some backstory...

An automated and high-throughput compatible platform to study beta cell proliferation in standardized 3D primary human islets. We worked very hard to develop this methodology and are very happy to see our work published. InSphero Boehringer Ingelheim frontiersin.org/articles/10.33…

SPATIAL GENOMICS entering the main stage! Proud seeing our Review Nature Reviews Genetics on #spatial profiling technologies out! Wonderful collaboration with Emma Lundberg Emma Lundberg and Jeff Moffitt. The future is now for in situ #singlecell genomics! nature.com/articles/s4157…

We're very happy to announce the latest release of Pancreatlas (v1.7), now offering the ability to filter and search across all bio-images at once (all 2,180‼). Check out pancreatlas.org and be sure to click through to Pathviewer to explore the data!

Very cool !

Chromatin accessibility profiling in tissue sections by spatial ATAC | Patrik Ståhl Enric Llorens bioRxiv biorxiv.org/content/10.110… | #chromatin #spatial #singlecell #atacseq #epigenomics