Must read #psychedelics Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors nature.com/articles/s4158…

I love all of our papers equally, but I might love this one a bit more. Rare to see complex molecule total synthesis, molecular neuroscience, and behavioral neuropharmacology in the same paper! Thanks to everyone who helped make this work possible pnas.org/doi/10.1073/pn…

Excited to see our new article is out in J. Am. Chem. Soc., comparing conformational equilibria of a human GPCR in lipid vesicles, nanodiscs, and detergents. Great work from students Arka Ray and Beining (Kim) Jin! pubs.acs.org/doi/10.1021/ja… #NMR #NMRchat

Why are animal models useful for CNS drug discovery? zendudest.substack.com/p/why-animal-m…

Psilocybin enters gastroenterology: First-ever psychedelic study targets treatment-resistant IBS | EurekAlert! eurekalert.org/news-releases/…

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks, and mechanistic screening nature.com/articles/s4158…

Molecular Design of Unimolecular Tetra-Receptor Agonists | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine science.org/doi/10.1126/sc…

5-HT2c agonists are gaining more attention. Looking forward to the results of our compound in phase 2 clinical trials Diazepine Agonists of the 5-HT2C Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352) | J Med Chem pubs.acs.org/doi/10.1021/ac…

For readers interested in GPCR drug discovery, here's a perspective on pharmacological characterization of GPCR modulators rdcu.be/esWfS and a review on functional dynamics studies revealing new approaches rdcu.be/esWgt

ShanghaiTech team just revealed the structure and functional mechanism of the human sweet taste receptor. The study was published in Nature on June 24! shanghaitech.edu.cn/eng/2025/0625/… Link of the paper: nature.com/articles/s4158…

UCSF’s Translational Psychedelic Research Program has made history by proving that psilocybin is not only safe in Parkinson’s patients, but there were significantly improved mood symptoms, and the most delightfully surprising result is that motor symptoms also improved! 🧵

Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder: A pharmacological challenge study sciencedirect.com/science/articl…

We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…

Cool!! Another use for BMB-101!! "5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA" nature.com/articles/s4138…

AbbVie in Talks to Acquire Gilgamesh in $1 Billion Deal bloomberg.com/news/articles/…

DEA Forwards Psilocybin Rescheduling Petition To HHS For Review via @forbes forbes.com/sites/ajherrin…

Adenosine A2a receptor plays an important role!

Breakthrough therapy designations in China and the United States nature.com/articles/d4157… This new article analyses breakthrough therapy programmes intended to help address unmet medical needs in the two countries

Nature research paper: Designing allosteric modulators to change GPCR G protein subtype selectivity go.nature.com/3L3dqvs