A human metabolic map of pharmacological perturbations reveals drug modes of action go.nature.com/3CreANg

"Foundations of Machine Learning" A 505-pages book from MIT for beginners is 💯 FREE.

🎓Nos enorgullece felicitar a nuestros y nuestras estudiantes de doctorado Universidad San Sebastián por haber logrado la adjudicación de una beca altamente competitiva en la Convocatoria 2025 de Becas de Doctorado Nacional y primer llamado de Beneficios Complementarios de este año

For readers interested in extracellular targeted protein degradation, here's a comprehensive review of the various strategies that are being explored tinyurl.com/3sef94dx rdcu.be/d9twH

How do AI-powered protein-ligand docking methods compare to traditional physics-based approaches in terms of accuracy, physical plausibility, and virtual screening performance?Nature Machine Intelligence "Benchmarking AI-powered docking methods from the perspective of virtual screening" •

Google just introduced an AI co-scientist. "To help uncover new, original knowledge and to formulate...novel research hypotheses...building upon prior evidence and aligned to scientist-provided research objectives and guidance." If it's half as good, it'll be revolutionary.

For readers interested in new epilepsy therapies in development, here's a comprehensive recent review nature.com/articles/s4157… rdcu.be/eaxv6

For readers interested in therapeutic strategies for Duchenne muscular dystrophy, here's a review nature.com/articles/s4157… rdcu.be/eaGft

For readers interested in cancer immunotherapy, this Review in our February issue discusses opportunties and challenges in using vaccines for cancer prevention nature.com/articles/s4157… rdcu.be/eaNxo

For readers interested in personalized therapeutics such as antisense oligonucleotides for ultra-rare diseases, this review from IRDiRC discusses progress in the field and provides a roadmap for their development nature.com/articles/s4157… rdcu.be/ea4yG

El último día de febrero se conmemora el día mundial de las #EnfermedadesRaras #PocoFrecuentes Rare Disease Day . En preparación para este día, compartiremos durante esta semana los resultados principales de nuestro trabajo de investigación colaborativa en el ICIM et al.

Solo falta el 10%....muy muy cerca de la meta!!! Aun puedes ADQUIRIR TU ENTRADA PARA MAÑANA O HACER TU DONACIÓN crowdfunding.4id.science 🗓️ *Sábado 1 de marzo* ⏰ *Entre 12 y 20 horas* 📍 *Villa Rovereto, Laguna de Aculeo, Paine* Te esperamos!

For readers interested in RNA-based medicines such as antisense oligonucleotides and siRNAs, here's a review discussing strategies to address challenges associated with their applicability, efficacy and safety profiles nature.com/articles/s4157… rdcu.be/eciEq

Identifying ligands for therapeutic targets among billions of compounds is challenging! Can we search ultra-large chemical libraries more efficiently? Yes! Read about our docking/ML approach: nature.com/articles/s4358…

Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed nature.com/articles/s4146…

For readers interested in siRNA therapies, here's a review nature.com/articles/s4157… rdcu.be/ef9IV

Wow, wow, wow!!! The structure of human sweetness cell.com/cell/fulltext/…

New Practical Cheminformatics Post, "Useful RDKit Utils - A Mötley Collection of Helpful Routines" patwalters.github.io/Useful-RDKit-U…

pubs.aip.org/aip/jcp/articl…

Libgen, Sci-Hub, and Z-library had millions of pirated academic books and papers. So, they were shut down. We shouldn't use them anyway. We should help billion-dollar academic publishers get richer. Anyway, here's how to access these libraries: Don't do this!