Perturbing the mind - our subjective experiences - naturally changes cardiac rhythms. This paper in mice shows that perturbing cardiac rhythm influences anxiety-like behaviors. The mind-body unit is unified through multiple bi-directional mechanisms. nature.com/articles/s4158…

Welcome to our new series featuring exciting findings related to the deep mind-body connection! Each week we will share an important finding submitted by psychobiology experts. Check out humanpsychobiology.org for more information, a resource created by Sophie Basarrate.

Check out this fun piece showcasing one of my favorite scientific papers (from the lab of J.O. Holloszy) of all time! The 1977 Exercise Protocol that Increased Fitness More than Any Other link.medium.com/KZj0fy4wRyb

Delighted to share our lab’s new preprint, a 🧵(1/n): biorxiv.org/content/10.110…

Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction dlvr.it/Sn6VKR

Mental illness is a brain disorder? Right? We thought so. Hang on though, our new study JAMA Psychiatry shows that poor body health is a more pronounced manifestation of mental illness than poor brain health. jamanetwork.com/journals/jamap… 🧵1/9

1. Excited to share our new story published today in @elife, a 🧵(1/n) elifesciences.org/articles/78335

Our lab’s first foray into sepsis metabolism is now published! 🧵 for more details. Congrats and thanks to Brooks Leitner and the rest of our team Yale Internal Medicine Yale MSTP

Biomarkers play a key role in informing health status, guiding treatment, and predicting disease. What makes a biomarker great? There are several essential features that determine the utility of a biomarker, including predictability and explainability. brooksmdphd.com/blog/2023/perf…

It's easy to think of neurotransmitters (& thus other metabolites, e.g. lactate) purely as signaling molecules. However, it is important to also consider their roles as metabolic intermediates in other biochemical processes. This great review covers both! nature.com/articles/nrn.2…

Intriguing study showing the cellular energetic consequences of dealing with chronic stress. All metabolic resources seem to go towards keeping up with ATP demand... What other cellular functions must be spared in order to keep up? Martin Picard

The first version of the "hallmarks of mitochondrial signal transduction" Thinking about 1) the INPUTS that mitochondria sense and respond to, 2) the PROCESSES they use to exchange information between organelles, 3) the SIGNALS they produce, what is this diagram missing?

Using natural abundance ratios allows for a significant increase in capacity for natural experiments in metabolism. Dissecting glutamine and glutamate with this methodology will bring exciting opportunity if and when used to study cell specific brain metabolism in people

REVIEW Vincent Prevot, Sreekala Nampoothiri, Ruben Nogueiras et al. present glial cells as key mediators of energy balance through integrating peripheral signals in discrete #brain regions, highlighting their relevance in metabolic diseases. nature.com/articles/s4225…

By applying high-throughput biological omics techniques, researchers find that organ systems respond uniquely to support liver antioxidant synthesis to fight sepsis. Read more from #YaleEndocrinology team ⬇️ Brooks Leitner Rachel Perry medicine.yale.edu/intmed/news-ar…

Delighted to share our new manuscript led by Xinyi Zhang with valued collaborators including Won Dong Lee Brooks Leitner just out in AJP-Endocrinology and Metabolism Yale Cancer Center Yale Internal Medicine journals.physiology.org/doi/full/10.11…

Week 30 of the Human Psychobiology Project series presents a finding about the connection between the gut microbiome and depression. This finding was submitted by Brooks Leitner, and more information can found at pubmed.ncbi.nlm.nih.gov/35508109/.

Very excited to announce the acceptance of Ascent Bio (our Yale University AI-therapeutics spinout company) into the Merck Digital Sciences Studio accelerator and funding from Merck, Northpond Ventures (Northpond Ventures), and McKesson (McKesson Ventures)! mds.studio/news/meet-our-…