Our latest paper is out! In collaboration with Anne Carpenter, PhD, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

Excited to share our latest on Mtb and antigen presentation (biorxiv.org/content/10.110…). Keep reading if you’re interested in host-pathogen interactions, vaccines, and human immunology! Led by @OwenKLeddy (on the postdoc market!).

Doing good science is 90% finding a science buddy to constantly talk to about the project.

RNF213 ubiquitylates LPS but also restricts LPS-free pathogens: bacteria, parasites and viruses! Is RNF213 an amazingly versatile pattern-recognition receptor (#PRR) or does it act downstream of specific PRRs? The answer hot from the EMBO Reports press: embopress.org/doi/full/10.10…

Excited to share the first project from my postdoc. We studied a ligand bound TRPV1 cryo-EM dataset with state of the art heterotgeneity methods, and developed a way to compare them with a technique we call CryoSVD. paper doi.org/10.1101/2024.1… CryoSVD github.com/flatironinstit…

Published today! Spatial proteomics reveals JAK/STAT as a target for Toxic Epidermal Necrolysis, an often fatal skin reaction to common medication. We validated our findings in pre-clinical models & successfully treated the first patients worldwide.🧵⬇️ nature.com/articles/s4158…

With some recent discourse in the #proteomics community around #OpenSource scientific software, I thought it was finally time to jot down my thoughts. I wrote a quick blog post, complete with my own 🌶️ takes. Here's some of what it contains: (1/2)

Positively thrilled to share that I've joined Arcadia Science as Chief of Staff to the CSO! I'm so excited to be working with Prachee Avasthi and the brilliant team of Arcadians as we reimagine the ways we do science and accelerate scientific progress for everyone.

Thank you all for your responses. To summarize, these are free/open source alternatives for preparation of scientific illustrations: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org

We identified the new autophagy adaptor IRGQ, which regulates MHC-1 levels and affects hepatic cancer growth. Huge thanks to @jwadeharperlab , Mancias Lab, Lina and Ivan Đikić for the collaboration. Hope you enjoy the read! cell.com/cell/fulltext/…

Thrilled to share our findings on NINJ1 autoinhibition, now online in nature. Big thanks to the amazing team Vishva Dixit Melissa Truong Matt Johnson Alexis Rohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)

I am very happy to share the first results from my postdoc in the Broz Lab. We investigated how the plasma membrane gets ruptured during #celldeath and discovered that cell swelling endows #NINJ1 filaments with the ability to induce rupture.

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

In the spirit of Halloween, I'm thrilled to share our latest preprint: #NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic #celldeath bioRxiv biorxiv.org/content/10.110… @LabSteinberg @GoldenbergLab Prof. Hao Wu Liron David Spencer Freeman

Protenix: Protein + X | ByteDance - A trainable PyTorch reproduction of AlphaFold 3 GitHub: github.com/bytedance/Prot…

Unique opportunity for creative scientists and engineers out there who are excited about open science and doing work for the public good. If you're one of them, apply now! 1-yr science residency with $125-250K in salary, in addition to other support (including compute).

Proud to share our work by a fantastic team, spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel. We developed an improved iAPEX-based #ProximityLabeling method for #massspec based subcellular #proteomics. biorxiv.org/content/10.110…

“No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue.” - President Alan Garber hrvd.me/GarberRespond3…

We did something radical that shouldn’t feel radical: we stopped funding science built for journals so that we can reimagine scientific publishing. First at Arcadia Science. Now at Astera Institute. More below.

I was proud to stand with more than 500 people in Stowe today at a No Kings protest. Today, all over the country, tens of thousands of Americans are saying NO to the authoritarianism that has taken hold of our country.