Our first official lab lunch! Ending the year on a well-deserved treat for these brave individuals who joined a lab that was a series of bare benches. But together we built a lab from the ground up, and are poised for some great science in 2024!

Our lab's latest is now out on BioRxiv. In this work we set out to understand how 'shieldin' regulates #DNArepair, focusing on its physiological function in B cells & pathological contributions to BRCA1-mutant cancers. Some background & take-home msgs (1/) biorxiv.org/content/10.110…

Our research on using AlphaFold2 to predict how peptides from disordered regions bind proteins has now been published with Springer Nature in Nature Communications I am very happy to share the updated paper with you 😀 rdcu.be/dwlLa

It is online! The first paper of the Noordermeer lab. Of course, this wasn't possible without the help of many others (see thread for more details). Congratulations to first authors Bert van de Kooij, Anne Schreuder and Raphael Pavani. sciencedirect.com/science/articl… 1/8

New preprint from the lab led by Sumin Feng ! We report that the ATP translocases FANCM and SMARCAL1 act redundantly to promote an essential function during DNA replication! biorxiv.org/content/10.110…

Sometimes working in a university on top of a mountain has its perks

Sometimes conferencing at a California beachside has its perks. GRC 2024 Ventura, let's go!

What a unique and great meeting this was, not even north of 32 mosquito bites detracted from the amazing science discussed! Thanks to organizers Raquel Cuella Martin Alejarez Alvandro @durocher1 for their hard work!

AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…

I'm looking for a grad student(s) to start in 2025! Students can gain broad experience in developmental genetics, signal transduction, and disease modeling. Located in beautiful Vancouver. Check out our website for details. verheyenlab.weebly.com Please R/T

My incubators came with two different height bases. Hopefully the people in my lab are less OCD than I am...

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

Anyone ever see the weird aberration in the first image? Doesn't look like pulverization. PARPi in BRCA1-mutated RPE. Expected radials, got these. Other image as reference of most spreads from other samples in the experiment.

Technical Report of HelixFold3 for Biomolecular Structure Prediction The PaddleHelix research team at Baidu have released their AlphaFold3 replication under an open-source noncommercial license. Performance approaches that of AlphaFold3. abs: arxiv.org/abs/2408.16975 website:

We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬 It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 dpmd.ai/3XuMqbX

We are thrilled to present you our work on BRCA1-BARD1 nature showing that the complex has a direct role in long-range DNA end resection. With Ilaria_Ceppi Maria Rosaria Dello Stritto and our collaborators Pablo Huertas' Lab Sylvie Noordermeer and Seidel labs. nature.com/articles/s4158…

It's been a blast contributing to this cool story!

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…