Thrilled to share our extension of the dTAG platform towards a universal strategy for direct protein control in Nature Communications. We present dTAGⱽ-1, an exclusively selective molecule that co-opts VHL to degrade tagged fusions in cells and in mice. nature.com/articles/s4146…

We are excited to announce our paper in Nature Genetics uncovering a role for minor introns in clonal hematopoietic disorders, Noonan Syndrome, and a diverse number of cancers. A collaboration between our lab (@sloan_kettering) and Robert K. Bradley (Fred Hutch Cancer Center): nature.com/articles/s4158…

Second Annual Meeting on Advances on Nuclear Topology and 3D Chromatin Architecture in Cancer Registration: nyulangone.zoom.us/webinar/regist…

Congratulations to first authors Biniam and Gabriela on their work!

Every child with cancer deserves a painless cure. Why would we ever settle for less? There is so much work to do but the Pan-Mass Challenge will help us get there. vimeo.com/573961459?ref=…

In this new study, we show that NAD homeostasis governed by NMNAT1 is critical for AML stem cells and suppressing this mechanism renders AML sensitive to venetoclax. advances.sciencemag.org/content/7/30/e…

Very pleased to share our work exploring the degradability of HDACs. While exploring this target family we observed collateral degradation of HDAC-containing complexes and cell line dependent isoform specificity! CellChemicalBiology cell.com/cell-chemical-…

Very excited that my work on TRIM8 in #Ewing sarcoma is now published in @CancerCell cell.com/cancer-cell/fu… #openaccess#pediatric#cancer#selective#dependency#fusion#oncoprotein#stability#degradation Dana-Farber Dana-Farber/Boston Children's

Congratulations to post-doc Alex Seong and team on the publication of this exciting work at Cancer Cell!

Online Now: TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma dlvr.it/S4hKVy

The Crompton lab is looking for post-docs, project managers, and experienced technicians to help our team accelerate NIH/DoD-funded research projects in pediatric solid tumors and in early detection for cancer predisposition syndromes. see more at: careers.dana-farber.org/jobs/?search_t…

Out today in Cancer Discovery from postdoc Shan Lin. "An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML." Congratulations Shan! Dana-Farber/Boston Children's

MSK inaugurates The Edward P. Evans Center for #MyelodysplasticSyndromes under the leadership of Dr. Omar Abdel-Wahab Abdel-Wahab Lab, who will also serve as the Center Director. @EdwardPEvansFdn bit.ly/3vXmLsV

Very excited to see our work now in print in the July issue of Cancer Discovery Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts aacrjournals.org/cancerdiscover…

Sharing with everyone this new publication led by Nathaniel Mabe,PharmD,PhD and Min Huang. An amazing collaboration with Majzner_Lab and demonstration of the power of the NCI PPG that brought us together. Looking forward to many more collaborations! nature.com/articles/s4301…

Excited to announce a new paper in Cancer Discovery on genetic, biological & therapeutic implications of mutations impacting degradation of RAS proteins in clonal hematopoietic disorders. Led by Sisi Chen and collaboration with Pau Castel and @ColemanLindsley aacrjournals.org/cancerdiscover…

Excited to share our newest story with JCI insight. A joint collaboration between William Hahn, Mariella Filbin , and Stegmaier Lab labs. VRK1 is a synthetic lethal target in neural-lineage cancers expressing low VRK2. insight.jci.org/articles/view/…

Check out our latest pub led by David Shulman Dana-Farber/Boston Children's with Children’s Oncology Group and Stegmaier Lab showing that loss of STAG2 protein expression by IHC is prognostic in localized Ewing sarcoma and significantly increases risk of relapse with distant mets. rdcu.be/cXikD

Happy to publish this opinion/review where we argue that endogenous retroelements act as a 'fire alarm' for disruptions to several cellular processes such as heterochromatin, splicing, RNA editing, among others. great work by Håvard T. Lindholm and Raymond Chen sciencedirect.com/science/articl…