And if you want to dig in further, check out our new Stanford Social Innovation Review piece on the topic. It has been awesome to partner with Anna McKelvey on this.

better than love alone, commitment is in the air Cate Hall - usefulfictions.substack.com/p/tying-yourse… Trevor Klee - trevorklee.substack.com/p/e-is-for-eng…

wow. we need more Claire Patterson's. ferociously: curious, creative, persistent, independent, agentic, humane, humble mentalfloss.com/article/94569/…

Had an enjoyable 2.5 hrs (!) talking to Gita Wirjawan on his Endgame Podcast, riffing on my usual themes: biography, energy, space, and metascience, with a bit of economics, geopolitics, and AI thrown in. Thanks Gita! youtu.be/Y-wsDaK5zp0?fe… via YouTube

Somehow I missed this terrific conversation with Kumar Garg, quietly one of the highest impact science philanthropy catalysts on the planet. (Nice one Jordan Schneider!) Proud to be working with Kumar & team at ARIA activation partner Renaissance Philanthropy 🧬🚀

I'll be in the Bay Area from the 1st to the 8th of July, and New York from the 9th to the 12th. DM me if want to meet about my biotech venture (Etheros; enzyme mimetics for inflammation / neurodegeneration) or the R&D productivity work.

I feel like everybody is using this app to be witty or show off & it's distorting my picture of the world. I want to hear about what's real and alive. What's your most pressing concern right now? What problem are you stuck on? What do you yearn for?

Hello World! Sharing the news here that I recently joined the team at @renphil21, where I’ll be helping fuel a 21st century renaissance by increasing the ambition of philanthropists, scientists, and innovators.

fda launching a new kind of priority review voucher with a 1-2month review. for programs that address health crisis, are innovative cure, unmet need, or national security manufacturing. that's a cool idea. fda.gov/news-events/pr…

Nicotine is a relatively weak primary reinforcer unlike cocaine and heroin, so why is its addiction so widespread but the habits so variable? I’d like to share our new perspective piece on why we need more human pharmacokinetics measurements to complete the picture.

Today's FreakTakes is a guest post from alex The question: what new financial instruments, akin to YC SAFE notes, could help researchers found way more BBNs? We'd love any ideas! And thanks to Tom Kalil, Tom Milton, and Ilan Gur for getting the brainstorm started

Wow. 10 of 12 patients no longer insulin dependent 1 year after transplant with allogeneic stem cell–derived islet cells! nejm.org/doi/full/10.10…

Initiatives such as Emergent Ventures & FAST Grants have shown the power of providing funding to ambitious individuals to pursue ideas that are too risky or bold to work on otherwise. Excited to be launching the Ember with ARIA to surface big if true ideas in the UK.

Chai's latest work is a big-deal breakthrough. Here is my non-biologist understanding: Proteins have complicated shapes in 3D, eg collagen is a triple helix. Each protein reacts or "binds" with other molecules that have a corresponding interlocking shape. (1/5)

As many of you know, I was so excited to announce our Big-if-True-Science Accelerator (BiTS) program earlier this year. Today, we are announcing details on the first cohort (with ARIA) and how you can apply:

I’m kicking off a new blog! First post uncovers a hidden gem in LA: Hollyhock House. I discuss humanistic design, neuro, and architecture. Future posts will be more science/tech oriented. But I had to talk about this work for its creativity par excellence. You know those tweets

Happy to share our manuscript published today on regulation of cardiac adaptation to exercise training by PGC-1α and GDF15 in Nature Cardiovascular Research! nature.com/articles/s4416…

Big news from 🇯🇵! We're excited to partner with JST 科学技術振興機構 to launch ASCENT, marking our our 3rd government partnership supporting ARPA-style R&D programs. 👇

UPDATE: The last month has been whirlwind for us at @renphil21 as we rapidly scale. I wanted to share a few of the highlights in case you missed it.

Meet the 10 scientists who will define the next decade of breakthrough innovation as the inaugural @SPRIND_org x Big if True Science Accelerator cohort. Here's what they're building 👇