🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Júlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110…

A new study from Alex Bick & Ferrell Lab labs led by incredible Brett Heimlich, Pawan Bhat & Alyssa Parker! Comprehensive multi-omic profiling of 66968 single cells unveils that TET2 & DNMT3A mutations in Clonal Hematopoiesis drive distinct inflammatory pathways,

Proud to share our findings on Primary and Secondary Graft Failure in patients receiving AlloHSCT + PTCy as GVHD prophylaxis A very special thanks to my grand-ACS Dr. Alex Ambinder for his awesome mentorship astctjournal.org/article/S2666-…

My lab is hiring postdocs to study aneuploidy's role in cancer! We're applying next-gen chromosome engineering approaches to uncover how gene dosage imbalances impact drug sensitivity, metabolism, immune evasion, and more. Send me your CV+cover letter if interested. Please RT!

TET2 clonal hematopoiesis is enriched among individuals receiving solid organ transplantation. While this didn't predict transplant outcomes, whether it plays a role in the ultimate transplant indication requires further study aacrjournals.org/clincancerres/… AACR Alex Silver

Beyond excited to share my first paper from my PhD Daniel Fazakerley Lab Inst Metabolic Science-Metabolic Research Labs now out in The EMBO Journal! Special thanks to Sam from TVPLab and Dougall Norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! 🧵below:

#Thayer team supporting #SaySarcoidosis #Awareness Campaign #FindACure! The Osler Medical Residency and they #challenge the #Barker firm to #SaySarcoidosis #sarcoidosis Johns Hopkins Department of Medicine Hopkins Pulmonary and Critical Care Medicine Johns Hopkins Rheumatology @mwsharp5 Stuart Ray Sanjay Desai

Pretty incredible! ⛅️

My latest story is about how a very old and very cheap drug has been quietly revolutionizing bone-marrow transplants. (1/3)

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…

Nature research paper: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity go.nature.com/3KCsk8x

A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In Nature Medicine led by Joseph Breeyear Jacklyn Hellwege Ayush Giri Todd Edwards Vanderbilt University Medical Center nature.com/articles/s4159…

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

👋 @WashUHeme is recruiting!!!🤩 We are seeking physician-scientist, clinical & research faculty candidates to join our expanding #HemeDreamTeam! More details here: facultyopportunities.wustl.edu/Posting/Detail… facultyopportunities.wustl.edu/Posting/Detail… facultyopportunities.wustl.edu/Posting/Detail… hematology.wustl.edu @WUDeptMedicine

We are delighted to share our latest findings today in nature. We describe cardiogenic regulation of sleep after cardiac injury. “Myocardial infarction augments sleep to limit cardiac inflammation and damage” nature.com/articles/s4158…

📢 New KFW Lab paper out now in Science Advances! 📢 We show that AML cells resist chemotherapy by reversing the ATP synthase reaction—supporting oxidative metabolism and maintaining mitochondrial membrane potential. 🔬🧬 👉 science.org/doi/10.1126/sc…

🧫 A practical protocol for multiplexed single-cell cytometry bridges #chemicalbiology and #cellbiology—empowering both novices and experts to explore functional assays with high-throughput precision. 👉 doi.org/10.1016/bs.mcb…

1/ Our new review is out today in Nature Reviews Cancer—on why therapeutic cancer vaccines are finally gaining traction after decades of setbacks. 🔗 rdcu.be/emkkd w/ Dr. Neeha Zaidi Dr. Elizabeth Jaffee Key takeaways below

Today in nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a