Heterobifunctional small molecules to modulate RNA function: Trends in Pharmacological Sciences …. Congratulations sandra and hamish (yuquan) and jess! cell.com/trends/pharmac…

We updated our methods to profile small molecule-RNA interactions (started 10 yrs ago), evolving to cellular transcriptome-wide, unbiased approaches. As further advances occur, they will be available as a preprint and at our lab's homepage biorxiv.org/cgi/content/sh…

What an exciting and intense week it has been! Surrounded by brilliant scientists and entrepreneurs from all corners of the world, I embarked on a captivating journey of discovery. Grateful for witnessing firsthand the groundbreaking work of AION Labs! Thanks Mati Gill & the team

Congratulations, Yuquan (Hamish) Tong. We ID RNAs bound by small molecules in cells versus ones cleaved by recruiting ribonuclease effector proteins. Amir also developed a pipeline to use the binding data to predict 3D rna small molecule pockets in human rnas, a hard. problem

Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell…

Join the upcoming webinar to hear the latest updates from our research lab, where we focus on innovative approaches to targeting RNA complexes. Hebrew University Pharmacy HUJI Faculty of Medicine - The Hebrew University

Our latest research is out in Macromolecular Bioscience! Congrats to Aseel & team on developing small molecule degraders targeting the oncogenic Lin28 protein. This work highlights the power of molecular glues and PROTACs in RBP modulation & cancer. onlinelibrary.wiley.com/doi/10.1002/ma…

Thank you, yissum and AFHU, for the wonderful opportunity to present our work! We are grateful for the chance to share our advancements in small-molecule RNA-targeted therapies.

We are very excited by this first disclosure of our large collaboration with the lab of Nikhil Munshi Dana-Farber using a cMYC mRNA degrader to affect Multiple Myeloma. ASH Annual Meeting sciencedirect.com/science/articl…

Excited to share our latest publication in Heliyon! We developed fluorescent probes using RIBOTAC tech to visualize RNase L activity in living cells—paving the way for novel recruiters & deeper insights into RNase L behavior. Congrats to Elias on his work! sciencedirect.com/science/articl…

RNA: From Biology to Drug Discovery symposium, April 14-15, 2025, at UF Scripps. Speakers include: Darnell , Maquat, Rinn, Krainer, Krichevsky, and more! Register wertheim.scripps.ufl.edu/departments/ce… #RNA #DrugDiscovery #Biology #UF #Scripps

Our recent article "PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28", is one of 4 articles from Macromolecular Bioscience (published in 2024) that is featured in the Editors Choice collection: onlinelibrary.wiley.com/page/journal/1… Thx for the recognition!

Our latest RSC Chem Bio review explores RNA-targeted small molecule libraries—their evolution, design principles, and drug discovery potential. We also highlight key challenges, like the need for better datasets for AI-driven RNA therapeutics. pubs.rsc.org/en/content/art…

Big thanks to Derek Lowe for the thoughtful commentary on our manuscript! Your insights on antifungal research and the challenges we face in drug discovery are invaluable. What the Antifungals Are Really Doing | Science | AAAS science.org/content/blog-p…

🚨We're Hiring! The School of Pharmacy seeks candidates for a tenure-track faculty position in Medicinal Chemistry! Please apply no later than August 31st, 2025 Apply now: ttp.ekmd.huji.ac.il/Pages/defaultE… #Hiring #MedicinalChemistry #AcademicJobs #Pharmacy #HUJI

Advancing target validation with PROTAC technology: Expert Opinion on Drug Discovery tandfonline.com/doi/full/10.10…

New opinion article out now: Advancing Target Validation with PROTAC Technology 🔹 Overview of clinical-stage degraders 🔹 in vitro & in cellulo validation assays 🔹 Insights for advancing novel degraders Read more: lnkd.in/dYFWFUAU Congrats to Leora & Aseel! Hebrew University

Noah built a platform to discover covalent small molecules that react with RNA. Many protein-reactive warheads also react with RNA. We then Converted a DNA binder into a rna covalent compound. Preprint: biorxiv.org/content/10.110… #RNA #CovalentDrugs #ChemicalBiology #DrugDiscovery