Thrilled to share that my first-author ADAD paper is now published in Cell (Principle) Cell ! 🎉 This exciting milestone comes just before I make the move to join Moffitt Cancer Center, where I'll be working with Dr. Yu and Dr. Li Roger Li . I am deeply grateful for the

Great overview by Alzforum on our recent Alzheimer's disease X chromosome wide association study, as well as 2 other similar studies that just came out. Very exciting to see all these new insights on the X! alzforum.org/news/research-…. jamanetwork.com/journals/jaman…

We identified Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease and validated it by CRISPR from Yin Shen Thanks The National Institute on Aging (NIA) Cleveland Clinic Lerner Research Institute Yin Shen alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Dementia prevention in Africa, a region with many modifiable risk factors, is critically needed. Our multinational Africa-FINGERS, led by the dynamo Dr Chi Udeh-Momoh & colls, offers innovative multidomain interventions tailored to the region's unique challenges➡doi.org/10.1002/alz.14…

Make sure to join us for AAIC advancement: APOE & Lipid Biology. There's going to be some great new insights into everything APOE! Abstract submission deadline is Dec 2. alz.org/apoe/overview.…

Integration of CSF proteomics, metabolomics and genetics identify causal and druggable targets for #Alzheimers disease The Cruchaga lab published two side-to-side manuscripts in Nature genetics (nature.com/articles/s4158…; nature.com/articles/s4158…). @WUADRC WashU Medicine Neurology

Double Nature Genetics publications requires some 😎😎😎😎. Very cool and showing the great working ongoing at the NeuroGenomics and Informatics Center center!

Amazing work by Laura_Ibanez and her lab identifying non-proteomics biomarkers, specifically circular RNAs for #Parkinsons, with AUC>0.95!! Impressive. Very pioneering work with important implications WashU Medicine Neurology. Supported by michaeljfox.org nature.com/articles/s4153…

Excited to share our work, new in Science Magazine: science.org/doi/10.1126/sc…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)

Calling all Sex and Gender Differences in AD PIA members! We need your help for the Year in Review webinar!!! This link is active through next Sunday -- alz.surveymonkey.com/r/SLH6BMW Please share your notable papers on sex/gender differences in AD! #SexGenderAD #Alzheimer'

What better way to start of the new year than registering for the year in review of #ADSexGenPIA. Everything you need to know on sex differences in Alzheimer's disease in 2024, packed in a 1 hour session!

Male-female comparisons are powerful in biomedical research. Unraveling and harnessing mechanistic etiologies of sex differences may reveal new diagnostics and therapeutics for the aging brain. More from us in the latest Neuron issue on aging. Bérénice A. Benayoun, PhD ctmurphy1.bsky.social

The X chromosome inherited from mom impairs cognition and speeds up brain aging. Check out our latest nature. UCSF Bakar Aging Research Institute UC San Francisco nature.com/articles/s4158… nature.com/articles/d4158…

This narrative that the amyloid hypothesis is a hoax based on a disgraced 2006 paper and has distracted us from the "real" cause of AD is everywhere these days. It's cropping up in The New York Times and now from RFK jr. It's fashionable. But it's inaccurate and destructive to the field.

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in Nature Genetics with Towfique Raj Panos Roussos Friedman Brain Institute nature.com/articles/s4158…

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in Science Advances Collaborators Berenice Benayoun, Bérénice A. Benayoun, PhD

CHOIR is officially published Nature Genetics. No more arbitrary decisions in clustering. Add this to your single-cell toolbox - it will save you so much heart ache. And now it can scale to millions of cells. Compliments of the very talented Cathrine Sant (Petersen).

X chromosome dosage compensation through the lens of human genetics! Females have two X chromosomes, but males have one. To compensate for this, one X is randomly inactivated in female cells. Some genes escape from this inactivation. Because both males and females are

Past eQTL studies have mostly focused on one gene at a time. But in the human genome, genes often occur in clusters and tend to be co-regulated by shared mechanisms. So why not consider neighboring genes together when mapping eQTLs? A new preprint tests this idea and introduces