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Stabilize the pts with HLH with steroids when still trying to figure out the diagnosis of #HLH/ #MAS Many drugs can be used...but important to balance infection risk with immunosuppression These are critical pts. Be vigilant.. #EULAR2025 Dr. John Cush

3 Fs of diagnosis of #HLH -Fever -Ferritin -Falling blood count Raising awareness is the key! Especially in rare diseases like this where the morbidity and mortality is super high! Collaboration between specialists help HLH networks will be helpful like this Dr. John Cush #EULAR2025

Software enhances treat to target outcomes for #RA GoTreatIT P0S0750 ##EULAR2025 Dr. John Cush

Rheumatology #AI to optimize rheumatology triage. Only 53 percent correlation between the AIs diagnosis with rheumatologists final diagnosis. Not sure if we want 47 percent pts to drop off...without a chance for diagnosis? #POS0883 #EULAR2025 Dr. John Cush

Treatment strategies for steroid free management of #relapsingpolychondritis 56 patients from a single center #POS0149 #EULAR2025 Dr. John Cush

Multimodal data using clinical histological and serological predictors in renal function in #sle nephritis. Using the AMP SLE data. Low baseline eGFR and histological damage predicted worsening renal function but not NIH activity index #POS0173 #EULAR2025 Dr. John Cush Andrea Fava

Procalcitonin can be used in the monitoring of infection, but is also high in Stills disease. 89 AOSD pts showed pts w high PCT had more pleuritis, MAS,^LFTs, & correlated w/ Dz activity, CRP, LDH, hi ferritin & normalized w bDMARD Rx. #EULAR2025 abstr #POS1118

Recommendations for RA management at #EULAR2025 - MTX [or other csDMARDs] and steroids still remain the first line- nothing beats that! - ofcourse minimize steroids! - rather than stopping meds at remission, reducing doses may be a better solution. Not much changed. Dr. John Cush

Will climate change impact rheumatological care? #EULAR2025 @rheumnow Especially larger cities are are affected more. Need to worry about comorbidities

RA is worst with temperature rising/ climate change. However SpA has the opposite effect! Climate change session at #EULAR2025 Dr. John Cush

Vector borne diseases that result in arthritis will rise with climate change/ flooding risk - Chikungunya - Dengue - Zika - West-Nile Virus Dr. John Cush #EULAR2025

Genicular artery embolisation is like so many interventions in MSK medicine: early promise with smaller RCT & observational data, but the later, more robust data doesn’t show the same benefit. If you do meta-analyses of all these data, you mix good with bad #EULAR2025 Dr. John Cush

Low disease activity more difficult to achieve in vulnerable populations. All rheumatic diseases - #RA #PsA #AS initiating DMARDs takes longer in these population #EULAR2025 Dr. John Cush

What do we know about disparities in #SLE - worse in women - worse in non white populations - have lower quality of care in vulnerable populations - have worse outcomes in vulnerable populations #EULAR2025 @rheumnow Diagnosis itself is difficult in communities with poor access

Dual pandemic in Africa. Increasing lifestyle diseases and obesity, along with infections and malnutrition. These may be reflected in rheumatic diseases too (if they could be studied in detail) #EULAR2025 Dr. John Cush

Targets for OA pain pharmacotherapies some by the wayside: - NGF - TrkA but some very much in play and exciting: - neurotrophin-3 - TRPV1 - Nav1.7, 1.8 Fiona Watt #EULAR2025 Dr. John Cush

Migrant health literacy challenges - Individual interviews with participants with rheumatic diseases (interpreters used) multiple aspects - Individual, Providers and system level Navigating health care systems #EULAR2025 Dr. John Cush