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Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding biorxiv.org/cgi/content/sh… #bioRxiv

Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! biorxiv.org/content/10.110…

Excited that this paper is out! Grp78/BiP/ HspA5 binds directly to TDP‑43 and mitigates toxicity associated with disease pathology A clever BioID to drive TDP-43 (not over-expressed) in cytoplasm and nucleus: which Hsp70 modulates TDP-43? rdcu.be/cNJCa 1/4

Honored to highlight exciting work from Barmada Lab elucidating mechanisms that regulate autophagy in neurons! sciencedirect.com/science/articl…

Nico Gomez from the Barmada Lab is primarily interested in exploring how the regulation of nucleic acid, the primary bearer of durable biological information across all living things, can be used to understand and treat disorders of the brain. Read more: rna.umich.edu/faculty/featur…

Congrats @SEWrightPhD!

Congratulations to Alison Narayan, who has been named a 2022 MBioFAR awardee! This #UMBiosciences award recognizes exceptional mid-career faculty in the biosciences and supports their continued pursuit of innovative, high-risk research. record.umich.edu/articles/six-u…

6 University of Michigan scientists & engineers have been named the 2022 winners of the #MBioFAR Award, which recognizes exceptional mid-career faculty in the biosciences. Congrats Barmada Lab Jianping Fu Lyssiotis Lab Alison Narayan, James Moon, Elizabeth Speliotes. news.umich.edu/six-u-m-resear…

Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)! - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430) - Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399) - Sumin Kim on neuronal NPC biogenesis (P2019/B339)

Also, Sami will be giving a talk on MTMR5 and neuronal autophagy at 4:53pm in the "Mechanisms of Autophagic and Endolysosomal Trafficking in Neuronal Function and Neurodegeneration" subgroup tomorrow! #CellBio2022

🎉NEW SPEAKER! 🗣️Dr. Sami Barmada Barmada Lab 🗓️15th June '23, 11 am EST 📝us06web.zoom.us/webinar/regist…

Our story on m6A and TDP43 is now out in Molecular Cell! sciencedirect.com/science/articl…

We have an opening for a postdoc! Come work with us on ALS/FTD ⬇️

Just OUT: A fantastic commentary on our paper by Emile Pinarbasi & Barmada Lab! Journal of Clinical Investigation doi.org/10.1172/JCI168… Thank you so much!

Our work on matrin3 is now out on PNAS: pnas.org/doi/10.1073/pn… Congratulations to all authors!

New preprint from our and Bill Dauer labs, also with @pappassa! Sumin Kim characterized neuronal NPC biogenesis and implicates mislocalized/delayed NPC assembly in DYT1 dystonia. See tweetorial below ⬇️