Principles and methods for transferring polygenic risk scores (PRS) across global populations nature.com/articles/s4157…

Join us next Wednesday online + LEARN HOW TO COMPUTE normative statistics for your brain MRIs using ENIGMA-Lifespan's CentileBrain.org JUST OUT in JAMA Psychiatry 👇👇💡💡🧠🧠 [1] pubmed.ncbi.nlm.nih.gov/37819650/ [2] ncbi.nlm.nih.gov/pmc/articles/P… [3] QR-CODE for next Wednesday's ONLINE

Postdoc position in FMRIB/WIN Analysis Group, Oxford with (brilliant & lovely) Rick Lange Rick Lange and Jesper Andersson. Help develop the new SoA multimodal nonlin alignment tool MMORF + new generation of multimodal brain templates+atlases. tinyurl.com/2s3c5ua5

A 25-year odyssey of genomic technology advances and structural variant discovery. #Genomics #Sequencing #StructuralVariants Cell cell.com/cell/fulltext/…

After seven (7!) years of work with >20 researchers at 10 different institutions, we are super excited to release NextBrain, a next-gen probabilistic atlas of the human brain with 333 regions: github-pages.ucl.ac.uk/NextBrain Preprint, data, code, videos, and much more in this 🧵(1/5)

Our new study led by @DoraKoller is out on molecularpsychiatry! Using #GWAS from PGC Consortium and VA Research MVP, we identified risk loci, cause-effect relationships, associations with cerebellum and amygdala linking #addiction to chronic #pain. Yale Psychiatry nature.com/articles/s4138…

Hey there 👋

Our updated summary on How to start a grassroots community from scratch? it's featured in the upcoming book 'Meta-Research and Development' by Busara Center, a guide for those in developing countries keen on #OpenScience & grassroots initiatives. 📚osf.io/mw72e

Trans-eQTL mapping in gene sets identifies network effects of genetic variants dlvr.it/T4w67y

Who is graduating a PhD from UCL?!

SMR Portal: an online analysis, visualisation, and database platform for mapping complex disease genes. Powered by Westlake FutureGene. Try it out at: yanglab.westlake.edu.cn/software/smr_p…. See a tutorial video at: yanglab.westlake.edu.cn/software/smr_p…

Genome-wide association studies focusing on SNPs have advanced our understanding of certain diseases but are reaching limits for some conditions. This Nature Reviews Genetics review highlights how exploring copy number variation can help break these limits. nature.com/articles/s4157…

🧬Useful GWAS resource from 260K individuals in Biobank Japan🇯🇵for 63 quantitative traits incl.: 👉hematology & blood cell counts 👉serum biochemistry & electrolytes 👉heart echo 👉blood pressure metrics 📊Summ stats: jenger.riken.jp/en/result 📜Paper: nature.com/articles/s4158…

New GWAS resource for intracranial & subcortical brain volumes🧠🧬 nature.com/articles/s4158… 👉N=74,898 from CHARGE+ENIGMA+UKB 👉254 loci 👉associations with neuro & psych diseases 📊summ stats (req application): enigma.ini.usc.edu/research/downl… 📰free preprint: medrxiv.org/content/10.110…

Yeah!

Our paper on the genetics of neuropathic pain is now online in Pain TODAY, which happens to be my birthday 🎂 Thank you, PAIN 🥸 check it out: journals.lww.com/pain/fulltext/…

🚀 Excited to share our new preprint on RICE, a PRS framework that integrates common and rare variants to enhance genetic risk prediction across diverse ancestries! Led by my postdoc fellow Jacob Williams, co-mentored with Xihao Li. Check it out here: medrxiv.org/content/10.110… 1/N

We are thrilled to share this work linking specific human brain cell types to psychiatric and neurological disorders, out now in Nature Neuroscience rdcu.be/d6Tcy See below for an overview and thanks to the amazing Tayden Li, William Giardino, Deis Sero, and so many others!

locuszoomr: an R package for visualising publication-ready regional gene locus plots academic.oup.com/bioinformatics… 🧬🖥️🧪 #Rstats github.com/myles-lewis/lo…

🎉 Join us in Cambridge this Sept for the 30th Anniversary of CLSS-UK! Day 1: ECR focus – careers, grants, editors & wellbeing Day 2: AI, robotics, omics & environment 🤝 Sponsors welcome! Let’s celebrate science & community! #CLSSUK30 #LifeSciences #ECR #Cambridge