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Very intriguing study in plants, showing that Arabidopsis exhibits a loss of epigenetic integrity during aging which can be manipulated and does not affect new organs. They suggest that a gene regulatory program sets the rate of epigenetic information loss during aging. Wow 🧐

Short Take: Investigating the Efficacy and Toxicity of Rejuvenation Interventions preprints.org/manuscript/202…

Gene behind orange fur in cats found at last science.org/content/articl…

Disagreement on foundational principles of biological aging Gladyshev Lab Yuri Deigin Eran Segal Prof Steve Horvath Daniel Belsky Morgan Levine @Joris_Deelen Brad English Patrick Griffin The Scheibye-Knudsen Lab Max Unfried george church Csaba Kerepesi Jesse Poganik Daniel Promislow Jarod Rutledge

Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice sciencedirect.com/science/articl…

Validation Requirements for AI-based Intervention-Evaluation in Aging and Longevity Research and Practice 🤖🧪 👇👨‍⚕️" 🔘We list 8 Requirements for good recommendations by Artificial Intelligence (Large Language Models) in giving longevity-related recommendations... 🔘Adding a

1/7 Excited to share our team’s first paper revealing how senescent cells use the GD3 ganglioside as a Senescence Immune Checkpoints (SICs) to bypass immune surveillance published in Nature Aging ! rdcu.be/d4XXJ

Animal and vegetal materials of mouse oocytes segregate at first zygotic cleavage: a simple mechanism that makes the 2-cell blastomeres differ reciprocally from the start academic.oup.com/molehr/advance…

Proud to share three papers from our lab rdcu.be/d2hUm, Anthony Letai MD PhD rdcu.be/d5rb3, and R. Bernards The Netherlands Cancer Institute rdcu.be/d5rjW all showing predictable mitochondrial control of senescent cell death, using BH3 profiling as a biomarker for senolytic therapy

I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity: aacrjournals-org.sire.ub.edu/cancerres/arti… 👩‍🔬🧪🔎 ⬇️

Published in Nature (2023), Kruse et al. (Tüting lab) demonstrate that adoptively transferred CD4+ T cells alone—but not CD8+ T cells—can eradicate melanoma tumors completely lacking both MHC class I and II expression. These findings challenge the current paradigm of cancer

Popular methods like UMAP & t-SNE are stochastic and distort data structure. Bonsai - a novel method - builds trees to relate high-dimensional objects, accounting for measurement noise. biorxiv.org/content/10.110…

very excited to read some cool papers on the logic underlying stress responses in mammals, so please submit your work :) #senescence #bioinformatics #inflammation #autophagy #longevity #cancer

Genuine epigenetic rejuvenation in primary cells has long been the holy grail. A groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated

Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a surprise: an 85% drop in NAD⁺ in mouse muscle leaves epigenetic age unchanged. Muscle structure, function, and mitochondria stay strong: NAD⁺ loss ≠ muscle

DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with Wanding Zhou lab. Kudos to Chin Nien Lee Chin Nien Lee and Hongxiang Fu! biorxiv.org/content/10.110…

At what point is it acceptable to name and shame authors submitting AI-generated articles? 5 hours into reviewing their manuscript? 🙃🙃🙃

Older patients with lupus display a marked drop in the expression of interferon stimulated genes and shifts in methylation epigenetic patterns, according to a clinical study that may explain why the condition becomes milder with age. scim.ag/4lc1BQU Science Translational Medicine

science.org/content/articl…

my cousin has just co-authored his first paper: sciencedirect.com/science/articl… super proud Dani! first of many 🍻 International validation study of AI-guided Craniofacial Superimposition in a contemporary population sample #AI #forensics #AcademicTwitter