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Featured Article: New study reveals neutrophil extracellular traps (NETs) drive hypercoagulability post-TAVR, and thus targeting NETs could prevent thrombotic complications ahajrnls.org/4jcy73j

In a multisite, real-world study of 24 patients with homozygous familial hypercholesterolemia, evinacumab was well-tolerated and reduced LDL-C by ~50% . Michael Wilkinson, Priyesha Bijlani, Michael Davidson MD, Pallavi Pradeep, Matthew Ito ahajrnls.org/3FMHglq

🚨 Catch up on the latest post on #ATVBnet! Don't miss out on the newest insights and updates. Read it here 👉 ahajrnls.org/3SUzucy

Carotid perivascular adipose tissue measured by MR imaging may serve as a novel imaging marker for ischemic stroke risk ahajrnls.org/4kyVdmr

Targeting METTL3-m6A-SLC7A11 axis may offer new therapy for AVF failure in dialysis patients. ahajrnls.org/4dZF1YS

Yang e t al. reported a novel role of PARP1 mediated PARylation dependent ubiquitination of POLG in vascular calcification. ahajrnls.org/3SRW6u6

Mechanistic studies provide explanation behind the genetic associations of carnitine palmitoyltransferase 1a with apolipoprotein B-containing lipoproteins Scott Gordon @RNHelsleyPhD ahajrnls.org/3HXePBY

Sortilin inhibition halts vascular calcification in male mice—highlighting a sex-specific E2-autophagy pathway Lupieri Adrien, PhD Aikawa-Aikawa Laboratories Elena Aikawa sasha Dakota Becker-Greene Prabhash Jha ahajrnls.org/3HLdoqi

Editor Pick: In human carotid atherosclerosis, plaque extravesicular vesicles (EVs) drive vascular cell communication and effector functions that typify vulnerability to rupture, which may precipitate symptomatic disease ahajrnls.org/3I6JBbS

Featured Article: Inflammatory signals induce metabolic changes essential for differentiation and calcification of aortic valve cells that mimic the phenotype of diseased valves ahajrnls.org/4l7E8zX

Featured Article: Elevated plasma mannose-binding lectin levels are associated with risk of future venous thromboembolism – The HUNT Study ahajrnls.org/45TpMi8

Current human genetic evidence does not support an adverse effect of lower FXI levels on heart failure risk or cardiovascular function Dipender Gill Iyas إياس ahajrnls.org/4lEadiX

LncRNA-536 sequesters RBM25, suppresses HOXB13 and promotes vascular smooth muscle proliferation, revealing new insight into PH ahajrnls.org/44PLG4H

FAM49B fragmentation by AEP promotes VSMC migration and induces increased atherosclerotic plaque burden ahajrnls.org/4lBB7I6

Editor Pick: In human carotid atherosclerosis, plaque extravesicular vesicles (EVs) drive vascular cell communication and effector functions that typify vulnerability to rupture, which may precipitate symptomatic disease ahajrnls.org/3I6JBbS

Featured Article: Inflammatory signals induce metabolic changes essential for differentiation and calcification of aortic valve cells that mimic the phenotype of diseased valves ahajrnls.org/4l7E8zX

Lamin A/C declines with age in immune cells, enhancing atherosclerosis progression. Human and mouse insights from Marta Amorós Alberto Del Monte CNIC ahajrnls.org/3Iwl5Bi

Featured Article: Elevated plasma mannose-binding lectin levels are associated with risk of future venous thromboembolism – The HUNT Study ahajrnls.org/45TpMi8

Targeting METTL3-catalyzed m6A RNA methylation on SGK1 mRNA suppressed vascular smooth muscle cell proliferation and alleviated intimal hyperplasia. ahajrnls.org/4eZiID5

This bone marrow transplant study provides additional support for the common notion that FXR does not play a prominent role in the functioning of macrophages. ahajrnls.org/4lUf6nW